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Vol. VI, No. 1 Fall 2002
A publication of Ohio University
J. O. Watson Endowed Research Chair |
OU-COM
Research Day She's Back! Welcome to Chris Knisely CORE Research Director Position Search IRB
Federal Wide Assurances Navigating
the NIH Grant Research and Scholarly Advancement Fellowship
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The Research and Scholarly Affairs Committee is showcasing research conducted at OU-COM by sponsoring Research Day on September 27, 2002, 12:00 - 1:00 PM. Posters describing research supported by the College will be presented on the bricks of Irvine Hall. Faculty and students will be available to discuss their research. Cider and doughnuts will be served. Everyone interested in learning more about research at OU-COM is invited and encouraged to attend.
Recent
comments have been that, "Chris Knisely is back in grants." If you
came to OU-COM after 1996, we can confirm the rumor -- she did work in COM's
grants office for several years. The Officer of Research and Grants, as
well as the College, is very fortunate now to have Chris in the position of
Director of Grant Development.
From 1998 until this past June Chris worked in Academic Affairs. Faculty persons who have served on CPC Block Teams may remember that she made "dunning requests" for learning objectives or forms. Staff persons may remember that she requested countless block team meetings. Chris doesn't regret a minute of that four-year opportunity. She gleaned a more intimate view of medical education and gathered a tremendous respect for faculty and staff who devoted many hours to the curricular endeavor.
Prior to Chris' work at OU-COM, she was Director of a National Science Foundation project at the College of Education. They organized summer institutes to provide graduate-level math and physics studies for middle-school teachers. Setting up a new program in thirteen Appalachian counties gave her a stronger appreciation of the dedicated teachers who persist in teaching environments despite sparse resources.
Before Chris' affiliation with Ohio University, she spent eleven years at the Ohio Humanities Council, a state-based agency of the National Endowment for the Humanities. Her experience at the Humanities Council was on the other side of the grants process, in awarding grants. Working on the giving side of grants made Chris more acutely aware of what funding agencies are asking for in a proposal. She always encouraged applicants searching for money to make a preliminary call to funding agencies. Chris thinks it's a better use of time to find out if your project idea matches the agency's funding priorities.
If you need assistance with grant proposal development, Chris can be reached at 740-593-2214 or by email at knisely@ohio.edu.
The search for the CORE Research Director is actively under way. The purpose of this position is to provide leadership and management of all aspects of research activities performed by physicians, residents, interns, and students in the form of design and critique of research protocols according to accepted research standards, and statistical support. This person will help researchers throughout the CORE system to perform valid studies that comply with federal regulations for the health and safety of human subjects, monitor residency research programs, enhance communication between CORE hospital Institutional Review Boards and the Ohio University Institutional Review Board, and provide support for the writing and editing of abstracts and papers.
OU-COM is seeking a person with a Master's degree (required) or a Ph.D. (preferred) in an area of science applicable to medical research. A working knowledge of clinical epidemiology and clinical sciences is desirable, a minimum of three years of research experience, including successful project organization, coordination and publications is required, and demonstrated success in obtaining research grants and experience in research consulting/mentoring capacity is necessary. The successful candidate also will demonstrate a high level of interpersonal skills, problem solving ability, ability to perform independently and good presentation skills.
For additional information, contact the search committee chair, Keith Watson, D.O., Associate Dean for Graduate Medical Education at 740-593-2229 (watson@ohio.edu) or Jack Blazyk, Ph.D., Associate Dean for Research & Grants at 740-593-1742 (blazyk@ohio.edu).
In an effort to facilitate approvals for research involving human subjects, the CORE Board agreed that each hospital's Institutional Review Board (IRB) will obtain a Federal Wide Assurance (FWA). This designation is awarded to IRBs that meet the application standards for strict quality and function. Ohio University has FWA status and will offer an inter-institutional agreement to CORE hospitals that comply. This agreement allows one FWA-designated IRB to acknowledge a proposal approved by another.
Currently, without an affiliated agreement in place, CORE residents, interns or students are required to submit their proposal for review by both IRBs before beginning data collection. With the agreement, the IRB process is streamlined by study approval of one IRB, and submission to the other IRB for acknowledgment. While data collection cannot proceed until both IRBs have reviewed the project, the net effect will be a marked reduction in time and effort in the approval process.
Protection of human subjects remains a critical part of clinical research. This improved process should maintain that protection while facilitating IRB review.
A seasoned principal investigator or a new investigator applying for a first National Institutes of Health (NIH) grant, is bound to pick up a few tips when browsing the new National Institute of Allergy and Infectious Diseases (NIAID) Web site called All About Grants at www.niaid.nih.gov/ncn/grants/default.htm. The site features three tutorials:
Grant Application Basics
How to Plan a Grant Application
How to Write a Grant Application
The tutorials integrate advice and opinions on the grant process culled from NIH staff, as well as from extramural scientists who have navigated the process themselves. Many of the tips relayed on the All About Grants site are relevant for all NIH R01 grant applications. How to Plan a Grant Application discusses the pros and cons of applying for a specific initiative, as opposed to sending in an unsolicited proposal, as well as what types of documents are needed when writing the application. How to Write a Grant Application is advice on what reviewers expect in a top-notch application and how to meet those expectations. There are also tips on writing and organizing the entire application, section by section. To learn what a scientific review administrator does or what "streamlined review" really means, then take a look at Grant Application Basics. This document describes the entire review process, from the time the application arrives at NIH until actually funding is received.
The deadline for R01 proposals is October 1, 2002. The Academic Research Enhancement Award (R15) proposal deadline is September 25, 2002.
Summa Health System received an NIH award entitled, "A Post-Discharge Intervention to Improve Stroke Outcomes." The principal investigator for this project is OU-COM graduate Kyle R. Allen ('86), a geriatric physician in the Akron area. Dr. Allen's project is a three-year study that consists of a randomized-control trial of 380 post-discharge ischemic stroke patients. This research follows a pilot study done at Summa Health System.
The primary aim of this study is to determine the effectiveness of an integrated post-discharge interdisciplinary stroke care model in improving stroke survivor's global well being. Stroke patients will be compared at the six months recovery point to those who receive usual post-discharge care. The study will look at a composite of neuromotor function, severe complications, management of risk for common post-stroke complications, quality of life, and stroke knowledge.
Robert Gotfried, D.O., and Jay Shubrook, D.O., in the Department of Family Medicine are primary investigators at OU-COM for a Phase IV diabetic research study. GOAL A1c is a multi-center, pharmaceutical- sponsored study looking at treating Type 2 diabetics with a form of insulin in addition to their current oral hyperglycemic medications.
To be eligible, subjects must have a diagnosis of Type 2 diabetes for at least one year, have a HbA1c > 7%, and be on stable doses of hyperglycemic medication for the previous 2 months. All study group procedures, medical care, and glucose meters are provided at no charge to the patient. All subjects will have five visits to the clinic in a 24-week period.
Contact Cammie Starner, R.N. at 593-2410 if you would like more details, or know of someone who would be interested in participating in this study.
Research
and Scholarly Advancement Fellowship
This past summer fourteen Phase II medical students participated in research projects with faculty mentors at OU-COM through the Research and Scholarly Advancement Fellowship program. This is a ten-week program that enhances hands-on research with weekly seminar topics related to research. The participants and their research topics included:
David Eland, D.O./Kellie Russell, Elizabeth Zmuda - Define relationships of fascia continuity for the iliacus muscle
Anthony Chila, D.O./Amber Boast - Norman J. Larson fellowship
Robert Gotfried, D.O./Melissa Gasaway, Alicia Parks - Compliance with antibiotic clinical guidelines: an assessment in the OU CORE
Mario Grijalva, Ph.D./Kim Wells - Tropical disease biology workshop & research program in Ecuador
Robert Hikida, Ph.D./Greg Johnson - Difference in muscle recovery between the young and the elderly after exercise induced soreness
John Howell, Ph.D./Katherine Binns - Is caffeine an effective diuretic?; Neil Ponder - The biophysical basis of carpopedal spasm and hypocalcemic tetany
Gillian Ice, Ph.D./Tim Kermode - Climate's role in the etiology of essential hypertension in African-Americans
Richard Klabunde, Ph.D./Mark Brauner - Effects of intracellular and extracellular antioxidants on ventricular dysfunction associated with ischemic-reperfusion injury
Felicia Nowak, Ph.D./Kim Nemeth - Characterization of the growth factor effects of PORF-1 and PORF-2 in cultured cells
Jay Shubrook, D.O./Ryan Colapietro, Jason Mazzurco - Examining a standardized curriculum in OMT and examining it effects on the use of osteopathic exams and OMT in the CORE
Poster displays of these projects will be presented during the OU-COM Research Day on September 27. They are also exhibited in Irvine Hall throughout the academic year. The call for faculty mentors will be circulated in January for the 2003 summer program. Descriptions of the research opportunities will be distributed to Phase I students in February and they will have until early March to apply for one of the positions available. For additional information, contact Judi Rioch, Program Director, at 740-593-2336.
by Chris Knisely
As I return to work with grants I'm excited about the merger of the Grants Office with the Research Office. What we offer internally to OUCOM faculty and staff is a more cohesive operation. What we offer in our collaboration with other Colleges in the University and the University Research office (ORSP) is a more efficient approach to our external funding. Finding funds for project ideas is sometimes elusive, but there are ways to make the process less painful and more expedient.
One of our goals is to advance your research and project ideas and to assist in locating funding. We can help investigate and identify possible sources of funding. We can support and participate in the production of effective and profession grant proposals.
Another goal of our office is to provide resources. Our office will jointly sponsor a workshop that will feature staff from OU Research & Sponsored Programs, Development Office, plus the Office of Research & Grants.
We will provide "template" language about OU-COM and its programs that can be used in grant applications. By September we will have this text available on this website.
Dan Smith, an OU-COM employee, shared another resource link that provides a guide to funding sources for local projects. The complete text can be found at the ILGARD web site (http://www.ilgard.ohiou.edu/pdf_files/GOA_funding.pdf).
I look forward to working with the faculty and staff in new program challenges and funding endeavors. Please give me a call at 740-593-2214 or email me at knisely@ohio.edu.
107th Annual American Osteopathic Association
Convention and Scientific Seminar
October 7 - 11, 2002
Las Vegas Convention Center, Las Vegas, NV
http://www.aoa-net.org/Convention/convention.htm
Student Osteopathic Medical Association
6th Annual National SOMA Student Research Program
October 9, 2002, 2:00 - 4:00 PM
Las Vegas Convention Center, Las Vegas, NV
Research Grants
Agency: American Heart Association
Title: Analysis of pUL34: a transcriptional regulator of the human cytromegalovirus immune evasion gene, US3
Amount: $214,500
Agency: Ohio Department of Development, Technology Action Fund
Title: Commercialization of novel peptides for the treatment of bovine mastitis
Amount: $747,413
Agency: NIH
Title: Design of novel linear cationic antimicrobial peptides
Amount: $145,000
PI: Xiao Chen, Ph.D.
Agency: Central Ohio Diabetes Association
Title: Identification of molecular targets of a plant-derived potent anti-diabetic compound
Amount:
$35,000
PI: Robert Gotfried, D.O.
Agency: Aventis Pharmaceutical
Title: GOAL A1c
Amount:
$4,000
PI: William Romoser, Ph.D., and Calvin James, Ph.D.
Agency: Cuyahoga Board of Health
Title: Testing of mosquitoes for LaCrosse encephalitis virus infection
Amount: $4,000
PI: Jay Shubrook, D.O.
Agency: Aventis Pharmaceutical
Title: GOAL A1c
Amount: $4,000
Program Grants
PI: Pat Burnett, Ph.D.
Agency: Health & Human Services
Title: Exceptional Financial Needs Award
Amount: $23,169
PI: Pat Burnett, Ph.D.
Agency: Health & Human Services
Title: Scholarships for Disadvantaged Students Award
Amount: $220,770
PI: Pat Burnett, Ph.D.
Agency: Health & Human Services
Title: Financial Aid for Disadvantaged Health Professional Students Award
Amount: $23,169
PI: Kathy Trace
Agency: Ohio Department of Health
Title: Child and family health services
Amount: $96,564