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Selected Publications:
D. Hirsh, J. Hammer, W.L.
Maloy, J. Blazyk
and J. Schaefer, Secondary structure and location
of a magainin analogue in synthetic phospholipid
bilayers, Biochemistry, 35, 12733-12741
(1996).
D. J. Hirsh, N. Lazaro,
L. R. Wright, J. M. Boggs, T. J. McIntosh, J.
Schaefer, and J. Blazyk,
A new monofluorinated phosphatidylcholine forms
interdigitated bilayers, Biophys. J., 75,
1858-1868 (1998).
E. Jo,
J. Blazyk, and
J. M. Boggs, Insertion of magainin into the lipid
bilayer detected using lipid photolabels,
Biochemistry, 37, 13791-13799 (1998).
J.
Blazyk, A.
Kearns, J. Hammer, L. Maloy and U. P. Kari,
Conformation and activity of antimicrobial peptides
related to PGLa, in Peptides: Frontiers of
Peptide Science, J.P. Tam and P.T.P. Kaumaya,
eds., Kluwer Academic Publishers, Dordrecht, 385-386
(1999).
J.
Blazyk, R.
Wiegand, J. Hammer, Y. Jin, Y. Zhang, F. Zhu, L.
Maloy and U. P. Kari, Comparison of the
properties of linear cationic antimicrobial peptides
that form alpha-helix vs. beta-sheet structure,
in Peptides 2000 , J. Martinez and J.-A.
Fehrentz, eds., EDK Publishers, Paris, 599-600
(2001).
J.M. Boggs, E. Jo, I.V.
Polozov, R.F. Epand, G.M. Anantharamaiah,
J. Blazyk, and
R.M. Epand, Effect of magainin, class L, and
class A amphipathic peptides on fatty acid spin
labels in lipid bilayers, Biochim. Biophys.
Acta, 1511, 28-41 (2001).
J.
Blazyk, R.
Wiegand, J. Klein, J. Hammer, R.M. Epand, R.F. Epand,
W. L. Maloy, and U. P. Kari, A novel linear
amphipathic β-sheet cationic peptide with enhanced
selectivity for bacterial lipids, J. Biol.
Chem., 276, 27899-27906 (2001).
J.
Blazyk, J.
Hammer, Y. Jin, Y. Zhang, and F. Zhu,
Relationship between amphipathic secondary structure
and activity in model linear cationic antimicrobial
peptides, in Peptides: The Wave of the Future,
M. Liebl and R. Houghten, eds., Kluwer Academic
Publishers, Dordrecht, 479-480 (2001).
Y. Jin, H. Mozsolits, J.
Hammer, E. Zmuda, F. Zhu, Y. Zhang, M. Aguilar, and
J. Blazyk,
Influence of tryptophan on lipid binding of linear
amphipathic cationic antimicrobial peptides,
Biochemistry, 42, 9395-9405 (2003).
J.
Blazyk, Y.
Jin, J. Hammer, M. Pate, A. Bobbey, J. Mellinger
,and E. Zmuda, Effects of glycine and alanine
substitutions on activity and selectivity in
amphipathic β-sheet antimicrobial peptides, in
Peptide Revolution: Genomics, Proteomics &
Therapeutics, M. Chorev & T. Sawyer, eds.,
American Peptide Society, 890-891 (2004).
O. Toke, W.L. Maloy, S.J.
Kim, J. Blazyk,
and J. Schaefer, Secondary structure and lipid
contact of a peptide antibiotic in phospholipids
bilayers by REDOR, Biophys. J., 87,
662-674 (2004).
H. Kamimori,
J. Blazyk, and
M. Aguilar, Lipid membrane-binding properties of
tryptophan analogues of linear amphipathic
beta-sheet cationic antimicrobial peptides using
surface plasmon resonance, Biol. Pharm. Bull.,
28, 148-150 (2005).
J.-X. Lu, K. Damodaran,
J. Blazyk, and
G.A. Lorigan, Solid state nuclear magnetic
resonance relaxation studies of the interaction
mechanism of antimicrobial peptides with
phospholipid bilayer membranes, Biochemistry,
44, 10208-10217 (2005).
Y. Jin, J. Hammer, M.
Pate, Y. Zhang, F. Zhu E. Zmuda, and
J. Blazyk,
Antimicrobial activity and structure of two linear
cationic peptide families with varying amphipathic
β-sheet and α-helical potential, Antimicrob.
Agents Chemother., 49, 4957-4964 (2005).
J.X. Lu,
J. Blazyk, and
G.A. Lorigan, Exploring antimicrobial peptide
KIGAKI membrane selectivity using solid-state NMR,
Biochim. Biophys. Acta, 1758,1303-1313 (2006).
E.Y. Chekmenev, B.S.
Vollmarb, K.T. Forseth, M.N. Manion, S.M. Jones,
T.J. Wagner, R.M. Endicott, B.P. Kyriss, L.M. Homem,
M. Pate, J. He., J. Raines, P.L. Gor’kov, W.W. Brey,
D.J. Mitchell, A.J. Auman, M.A. Ellard-Ivey,
J. Blazyk, and
M. Cotten, Investigating molecular recognition
and biological function at interfaces using
piscidins, antimicrobial peptides from fish,
Biochim. Biophys. Acta, 1758, 1359-1372 (2006).
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