Publications
(selected from total of 47)
Venken K, Moverare-Skrtic S, Kopchick JJ,
Coschigano KT, Ohlsson C, Boonen S, Bouillon R,
Vanderschueren D: Impact of Androgens, Growth
Hormone and IGF-I on Bone and Muscle in Male Mice
during Puberty. J Bone Miner Res, in press, 2006
Zhang X, Mehta RG, Lantvit DD, Coschigano KT,
Kopchick JJ, Green JE, Hedayat S, Christov KT,
Unterman TG, Swanson SM: Inhibition of estrogen
independent mammary carcinogenesis by disruption of
growth hormone signaling. Carcinogenesis, in press,
2006.
Coschigano, K.T..
(2006) Aging-related characteristics of growth
hormone receptor/binding protein gene-disrupted
mice. AGE 28:191-200.
Berryman, D.E., List, E.O., Kohn, D.T.,
Coschigano, K.T., Seeley, R.J., Kopchick, J.J.
(2006) Effect of growth hormone on susceptibility
to diet-induced obesity. Endocrinology
147:2801-2808.
Venken, K., Schuit, F., Van Lommel, L., Tsukamoto,
K., Kopchick, J.J., Coschigano, K., Ohlsson,
C., Moverare, S., Boonen, S., Bouillon, R.,
Vanderschueren, D. (2005) Growth without growth
hormone receptor: estradiol is a major growth
hormone-independent regulator of hepatic igf-I
synthesis. J Bone Miner Res 20, 2138-2149.
Machado, M.O., Hirata, R.D., Sellitti, D.F., Iotti,
R., Iotti, A., Cusumano, A.M., Riordan, G.P.,
Coschigano, K.T., Kopchick, J.J., Zuhl, I.,
Nguyen, N., Hirata, M.H., Doi, S.Q. (2005) Growth
hormone promotes glomerular lipid accumulation in
bGH mice. Kidney Int 68, 2019-2028.
Boyce, K., Kriete, A., Nagatomi, S., Kelder, B.,
Coschigano, K., Kopchick, J.J. (2005)
Phenotypical Enrichment Strategies for Microarray
Data Analysis Applied in a Type II Diabetes Study.
Omics 9, 251-265.
Wang, Z., Prins, G.S., Coschigano, K.T., Kopchick,
J.J., Green, J.E., Ray, V.H., Hedayat, S., Christov,
K.T., Unterman, T.G., Swanson, S.M. (2005)
Disruption of growth hormone signaling retards early
stages of prostate carcinogenesis in the c3(1)/t
antigen mouse. Endocrinology 146, 5188-5196.
Itoh, E., Iida, K., Kim, D.S., Del Rincon, J.P.,
Coschigano, K.T., Kopchick, J.J., Thorner, M.O.
(2004) Lack of contribution of 11betaHSD1 and
glucocorticoid action to reduced muscle mass
associated with reduced growth hormone action.
Growth Horm IGF Res 14, 462-466.
Iida, K., Itoh, E., Kim, D.S., del Rincon, J.P.,
Coschigano, K.T., Kopchick, J.J., Thorner, M.O.
(2004) Muscle mechano growth factor is
preferentially induced by growth hormone in growth
hormone-deficient lit/lit mice. J Physiol 560,
341-349.
Iida, K., del Rincon, J.P., Kim, D.S., Itoh, E.,
Coschigano, K.T., Kopchick, J.J., and Thorner,
M.O. (2004). Regulation of full-length and
truncated growth hormone (GH) receptor by GH in
tissues of lit/lit or bovine GH transgenic mice. Am
J Physiol Endocrinol Metab 287, E566-573.
Liu, J.L., Coschigano, K.T., Robertson, K.,
Lipsett, M., Guo, Y., Kopchick, J.J., Kumar, U., and
Liu, Y.L. (2004). Disruption of growth hormone
receptor gene causes diminished pancreatic islet
size and increased insulin sensitivity in mice. Am J
Physiol Endocrinol Metab 287, E405-413
Nass, R., Liu, J., Hellmann, P., Coschigano, K.T.,
Gaylinn, B., Berryman, D.E., Kopchick, J.J., and
Thorner, M.O. (2004). Chronic changes in peripheral
growth hormone levels do not affect ghrelin stomach
mRNA expression and serum ghrelin levels in three
transgenic mouse models. J Neuroendocrinol 16,
669-675.
Young, W.G., Ramirez-Yanez, G.O., Daley, T.J., Smid,
J.R., Coschigano, K.T., Kopchick, J.J., and
Waters, M.J. (2004). Growth hormone and epidermal
growth factor in salivary glands of giant and dwarf
transgenic mice. J Histochem Cytochem 52,
1191-1197.
Berryman, D.E., List, E.O., Coschigano, K.T.,
Behar, K., Kim, J.K., and Kopchick, J.J. (2004).
Comparing adiposity profiles in three GH mouse
models. Growth Horm IGF Res 14, 309-318.
Iida, K., del Rincon, J.P., Kim, D.-S., Itoh, E.,
Nass, R., Coschigano, K.T., Kopchick, J.J.,
and Thorner, M.O. (2004). Tissue-specific regulation
of growth hormone (GH) receptor and insulin-like
growth factor-I gene expression in the pituitary and
liver of GH deficient (lit/lit) mice and transgenic
mice that overexpress bGH or a bGH antagonist.
Endocrinology 145, 1564-1570.
ADDIN EN.REFLIST Smid,
J. R., Rowland, J. E., Young, W. G., Daley, T. J.,
Coschigano, K. T., Kopchick, J. J., and
Waters, M. J. (2004). Mouse cellular cementum is
highly dependent on growth hormone status. J Dent
Res 83, 35-39.
Coschigano, K.
T., Holland, A. N.,
Riders, M. E., List, E. O., Flyvbjerg, A., and
Kopchick, J. J. (2003). Deletion, but not
antagonism, of the mouse growth hormone receptor
results in severely decreased body weights, insulin
and IGF-1 levels and increased lifespan.
Endocrinology 144, 3799-3810.
List, E. O.,
Coschigano, K. T., and Kopchick, J. J. (2001).
Growth hormone receptor/binding protein (GHR/BP)
knockout mice: a 3- year update. Mol Genet Metab
73, 1-10.
Kopchick, J. J., Okada,
S., and Coschigano, K. T. (2001). Lessons
from growth hormone (GH) antagonist and GH receptor
'knockout' mice. In Targets for growth hormone and
IGF-1 action, R. Bouillon, ed. (Bristol,
BioScientifica Ltd.).
Coschigano, K.
T., Clemmons, D., Bellush,
L. L., and Kopchick, J. J. (2000). Assessment of
growth parameters and life span of GHR/BP
gene-disrupted mice. Endocrinology 141,
2608-2613.
Kopchick, J. J.,
Bellush, L. L., and Coschigano, K. T. (1999).
Transgenic models of growth hormone action. Annual
Review of Nutrition 19, 437-461.
Zhou, Y., Xu, B.
C., Maheshwari, H. G., He, L., Reed, M., Lozykowski,
M., Okada, S., Cataldo, L., Coschigano, K.,
Wagner, T. E., et al. (1997). A mammalian
model for Laron syndrome produced by targeted
disruption of the mouse growth hormone
receptor/binding protein gene (the Laron mouse).
Proc Natl
Acad Sci U S A 94, 13215-13220.
Meeting
Abstracts
(selected from total of 31 since 2000)
Coschigano, K.T.,
Malgor, R., Keller, C.M. (2006) Testing the
protective capabilities of Kidney Androgen Regulated
Protein (KAP) against diabetic nephropathy in mice.
The Endocrine Society 88th Annual
Meeting, Boston, MA.
Gosney, E.S., Coschigano, K.T., Kopchick,
J.J. (2005) Naked plasmid DNA injection of human
growth hormone (hGH) into the tail vein of mice
results in high serum levels of hGH: A jaunt into
hydrodynamics-based gene transfer. The Endocrine
Society 87th Annual Meeting, San Diego,
CA.
Zhang, X., Lantvit, D., Unterman, T.G.,
Coschigano, K.T., Kopchick, J.J., Green, J.E.,
Christov, K., Hedayat, S., Swanson, S.M. (2005)
Disruption of growth hormone signaling prevents
estrogen independent mammary carcinogenesis. The
Endocrine Society 87th Annual Meeting,
San Diego, CA.
Stevenson, A.E., Davies, J.S., Coschigano, K.T.,
Kopchick, J.J., Wells, T. (2005) Adiposity
profiles in rodent models of profound and moderate
GH-deficiency. The Endocrine Society 86th
Annual Meeting, New Orleans, LA.
Keller, C.M., Holland, A.N., Kopchick, J.J.,
Coschigano, K.T. (2004) Kidney
androgen-regulated protein (KAP) mRNA is decreased
in two mouse models of diabetic nephropathy. The
Endocrine Society 86th Annual Meeting,
New Orleans, LA.
Coschigano, K.T.,
Boyce, K.S., Matheny, G.E., Kriete, A., Dela Cruz,
S., Braughler, M., Kopchick, J.J. (2004)
Down-regulation of actin-related muscle genes in
obesity-induced diabetic mice as revealed by
microarray analysis. The Endocrine Society 86th
Annual Meeting, New Orleans, LA.
Coschigano, K.T.,
Boyce, K.S., Matheny, G.E., Kriete, A., Dela Cruz,
S., Braughler, M., Kopchick, J.J. (2004)
Microarray analysis of pancreatic tissue of
obesity-induced diabetic mice reveals
down-regulation of genes involved in glutathione
metabolism. The Endocrine Society 86th
Annual Meeting, New Orleans, LA.
Gosney, E.S., Riders, M.E., Coschigano, K.T.,
Kopchick, J.J. (2004) Diverse expression patterns
of three novel cDNAs indentified in the liver of
GHR/BP gene-disrupted mice. The Endocrine Society
86th Annual Meeting, New Orleans, LA.
Riders, M.E., Coschigano, K.T., and Kopchick,
J.J. (2003) Growth hormone receptor/binding
protein gene-disrupted (GHR/BP -/-)mice express a
novel cDNA. The Endocrine Society 85th
Annual Meeting, Philadelphia, PA.
Coschigano, K.T.,
Rasch, R., Holland, A.N., Flyvbjerg, A., and
Kopchick, J.J. (2003) Effects of a growth hormone
antagonist and a high fat diet on glomerular
morphology. The Endocrine Society 85th
Annual Meeting, Philadelphia, PA.
Coschigano, K.T.,
Holland, A.N., Riders, M.E., and Kopchick, J.J.
(2002) Phenotypic comparisons of two dwarf mice:
The bGH-antagonist mouse and the growth hormone
receptor/binding protein gene-disrupted mouse. The
Endocrine Society 84th Annual Meeting,
San Francisco, CA.
Coschigano, K.T.,
Riders, M.E., Holland, A.N., and Kopchick, J.J.
(2002) Altered growth hormone signaling in two
lines of dwarf mice results in diet-induced obesity
and hyperinsulinemia but not diabetes. The
Endocrine Society 84th Annual Meeting,
San Francisco, CA.
Coschigano, K.T.,
Holland, A.N., Rasch, R., Flyvbjerg, A., and
Kopchick, J.J. (2001). Diet-induced obesity in
growth hormone antagonist mice results in
hyperglycemia but not diabetes. The Endocrine
Society 83rd Annual Meeting, Denver, CO.
Coschigano, K.T.,
Riders, M.E., Jessen, N., Lund, S., Flyvbjerg, A.,
and Kopchick, J.J. (2001). Regulation of major
urinary protein gene expression in GHR/BP
gene-disrupted, bGH and bGH antagonist transgenic
mouse livers and experimentally induced cirrhotic
rat livers. The Endocrine Society 83rd
Annual Meeting, Denver, CO.
Patent Applications
Kopchick, J.J., Coschigano, K.T., Boyce, K.S.,
and Kriete, A. Diagnosis and treatment methods
related to aging, especially in muscle. Filed
4/29/04
Kopchick, J.J., Coschigano, K.T., Boyce, K.S.,
and Kriete, A. Diagnosis of hyperinsulinemia and
type II diabetes and protection against same based
on genes differentially expressed in muscle cells.
Filed 2/26/04
Kopchick, J.J., Coschigano, K.T., Boyce, K.S.,
and Kriete, A. Diagnosis of hyperinsulinemia and
type II diabetes and protection against same based
on genes differentially expressed in pancreas cells
(III). Filed 11/6/03
Kopchick, J.J., Riders, M.E., and Coschigano, K.T.
Diagnosis and treatment methods related to aging
(III). Filed 7/8/03
Kopchick, J.J.,
Coschigano, K.T., and
Holland, A.N. Diagnosis of kidney
damage and protection against same. Filed 8/2/02 |
