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Karen
Coschigano, Ph.D.
Associate Professor,
Molecular/Cellular Biology
Department of Biomedical Sciences
coschigk@ohio.edu
Academic & Research Center 302D
740-593-2196 |
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Research Interests: My main research goal has
been to identify and determine roles for genes
involved in growth, obesity, diabetes and aging. My
current research focuses on elucidating genes
involved in the development of or protection from
kidney damage either as a result of diabetes or
over-expression of growth hormone. My research
models include chemically induced type I diabetic
mice, high fat diet induced type II diabetic mice,
and transgenic mice with varying degrees of growth
hormone action. I use molecular techniques such as
cDNA subtraction, differential hybridization,
microarray analysis, northern and western analyses,
and real-time reverse transcription polymerase chain
reaction to examine differences in gene expression
between wild-type control mice and the experimental
mice. I have identified a number of candidate genes
whose expression may cause kidney damage or result
in protection from kidney damage due to diabetes or
growth hormone over-expression. I am currently
testing these findings in mice. |
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