Richard E. Klabunde, Ph.D.
Associate Professor of Physiology
Department of Biomedical Sciences
klabunde@ohio.edu
304 Irvine Hall
740-593-9468
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DEPT. OF BIOMEDICAL SCIENCES
DEPT. OF BIOLOGICAL SCIENCES
EDISON BIOTECHNOLOGY INSTITUTE
COLLEGE OF OSTEOPATHIC MEDICINE
 
 
  1. SB Bender and RE Klabunde.  Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and a1-adrenoceptor-medicated vasoconstriction in type 2 diabetes.  Am J Physiol Heart Circ Physiol 293:H2281-2288, 2007.

  2. RE Klabunde, KM Ryan and CE Paxson.  Effects of acute hyperglycemia on coronary vascular function in isolated, perfused rat hearts. Diabetes, Obesity & Metabolism 9:696-705, 2007.

  3. SB Bender, EK Herrick, ND Lott and RE Klabunde.  Diet-induced obesity and diabetes reduce coronary responses to nitric oxide due to reduced bioavailability in isolated mouse hearts.  Diabetes, Obesity & Metabolism 9:688-696, 2007.

  4. RE Klabunde.  Interviewing in industry versus academia.  The Physiologist 49: 260-261, 2006.

  5. Klabunde, RE.  Cardiovascular Physiology Concepts. Lippincott Williams & Wilkins/Baltimore, 2004. 

  6. Klabunde, RE.  Chapter 10: Secondary Hypertension, In, Hypertension Sourcebook, 1st edition, Omnigraphics/Detroit, 2004.

  7. Berrizbeitia, LD, LB McGrath and RE Klabunde. Oxygen modulation of superoxide radical injury in the Krebs perfused, isolated rabbit heart. J Invest Surg 15:251-257, 2002.

  8. Klabunde, RE and DE Anderson. Role of nitric oxide and reactive oxygen species in PAF-induced microvascular leakage. J Vasc Res 39:238-245, 2002.

  9. Klabunde, RE and DE Anderson. Obligatory role of nitric oxide in PAF-induced leakage in the hamster cheek pouch microcirculation. Eur J Pharmacol 404:387-394, 2000. [See Medline Record]

  10. McHugh, NA, A Solowiej, RE Klabunde and GF Merrill. Acute coronary vascular and myocardial perfusion effects of conjugated equine estrogen in the anesthetized dog. Basic Res Cardiol 93:470-476, 1998. [See Medline Record]

  11. Klabunde, RE and LJ Mulligan. The ferret as a model for myocardial infarct size reduction by a selectin inhibitor. Lab Animal Sci 48:529-532, 1998. [See Medline Record]

  12. Klabunde, RE, J Tse and HR Weiss. Guanylyl cyclase inhibition reduces contractility and decreases cGMP and cAMP in isolated rat hearts. Cardiovasc Res 37:676-683, 1998. [See Medline Record]

  13. O’Brien, PJ, GQ Li, M Locke, RE Klabunde and CD Ianuzzo. Compensatory up-regulation of cardiac SR Ca++-pump by heat shock counteracts SR Ca++-channel activation by ischemia/reperfusion. Mol Cell Biochem 173:135-143, 1997. [See Medline Record]

  14. HR Weiss, JD Sadoff, PM Scholz and RE Klabunde. Nitric oxide reduces myocardial contractility in isoproterenol-stimulated rat hearts by a mechanism independent of cyclic GMP or cyclic AMP. Pharmacology 55:202-210, 1997. [See Medline Record]

  15. Laniyonu, A, A Coston and RE Klabunde. Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. Shock 7:49-54, 1997. [See Medline Record]

  16. Klabunde, RE, WA Anderson, M Locke, SE Ianuzzo and CD Ianuzzo. Regional blood flows in the goat latissimus dorsi muscle before and after chronic stimulation. J Appl Physiol 81:2365-2372, 1996. [See Medline Record]

  17. Anderson, WA, CD Ianuzzo and RE Klabunde. Cardiomyoplasty: Studies on goat latissimus dorsi blood flow and muscle damage following surgical dissection and chronic electrical stimulation. J Card Surg 11:237-246, 1996. [See Medline Record]

  18. Ianuzzo, CD, SE Ianuzzo, M Locke, C Brdlik, WA Anderson, J Gu and RE Klabunde. Preservation of the latissimus dorsi muscle during cardiomyoplasty surgery. J Card Surg 11:99-108, 1996. [See Medline Record]

  19. Ianuzzo, CD, SE Ianuzzo, N Carson, M Feild, M Locke, J Gu, WA Anderson and RE Klabunde. Cardiomyoplasty: degeneration of the assisting skeletal muscle. J Appl Physiol 80:1205-1213, 1996 [See Medline Record]

  20. Pacholewicz, JK, M Adkins, WJ Boris, J Gu, C Xenachis, R Klabunde, T Jasionowski and LB McGrath. Evaluation of cryopreserved internal thoracic artery as a coronary bypass graft: evidence for preserved functional metabolic and structural integrity. Eur J Cardiothoracic Surg 10:20-25, 1996. [See Medline Record]

  21. Klabunde, RE and C Calvello. Inhibition of endotoxin-induced microvascular leakage by a PAF antagonist and 5-lipoxygenase inhibitor. Shock 4:368-372, 1995. [See Medline Record]

  22. Locke, M, RM Tanguay, RE Klabunde and CD Ianuzzo. Enhanced post-ischemic myocardial recovery following exercise induction of HSP 72. Am J Physiol 269:H320-H325, 1995. [See Medline Record]

  23. Klabunde, RE and AF Coston. Nitric oxide synthase inhibition does not prevent cardiac depression in endotoxic shock. Shock 3:73-78, 1995. [See Medline Record]

  24. RE Klabunde & R Mercado.  Drugs, Derivatives, and Heart Disease, In: Calculus with Applications, edited by ML Lial, CD Miller and RN Greenwell, Harper Collins/New York, 5th edition, 1993.

  25. Klabunde, RE, KJ Slayton and RC Ritger. NG-monomethyl-L-arginine (NMA) restores arterial blood pressure in hemorrhaged rats. Circ Shock 40:47-52, 1993. [See Medline Record]

  26. Klabunde, RE, ND Kimber, JE Kuk, MC Helgren and U Forstermann. NG-methyl-L-arginine (NMA) decreases contractility, cGMP and cAMP in isoproterenol-stimulated rat hearts in vitro. Eur J Pharmacol 223:1-7, 1992. [See Medline Record]

  27. Klabunde, RE and MC Helgren. Cardiovascular actions of NG-monomethyl-L-arginine are abolished in canine model of high-dose endotoxin. Res Commun Chem Path Pharmacol 78:57-68, 1992. [See Medline Record]

  28. Klabunde, RE and RC Ritger. NG-monomethyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biophys Biochem Res Commun 178:1135-1140, 1991. [See Medline Record]

  29. Klabunde, RE, RC Ritger and MC Helgren. Cardiovascular actions of inhibitors of EDRF (nitric oxide) formation/release in anesthetized dogs. Eur J Pharmacol 199:51-59, 1991. [See Medline Record]

  30. Voytik, S, SF Badylak, S Burke, RE Klabunde, J Henkin and A Simmons. The protective effect of heparin in a dog model of rethrombosis following pharmacologic thrombolysis. Thromb Haemostasis 64:438-444, 1990. [See Medline Record]

  31. Klabunde, RE, MC Helgren, T Opgenorth and E Novosad. Atrial natriuretic peptide does not inhibit the basal vascular tone present in the in situ blood-perfused dog gracilis muscle. Life Sci 47:2027-2033, 1990. [See Medline Record]

  32. Klabunde, RE, SE Burke and J Henkin. Enhanced lytic efficacy of multiple bolus injections of tissue plasminogen activator in dogs. Thromb Res 58:511-517, 1990. [See Medline Record]

  33. Laughlin, MH, RE Klabunde, MD Delp and RB Armstrong. Effects of dipyridamole on muscle blood flow in exercising miniature swine. Am J Physiol 257:H1507-H1515, 1989. [See Medline Record]

  34. Klabunde, RE, DE McDowell, RM High and R Ball. The hemodynamics of simple and sequential ilio-femoral grafts in dogs three months after insertion. Curr Surg 46:451-456, 1989. [See Medline Record]

  35. Badylak, SF, S Voytik, RE Klabunde, J Henkin and M Leski. Bolus dose response characteristics of single chain urokinase plasminogen activator and tissue plasminogen activator in a dog model of arterial thrombosis. Thromb Res 52:295-312, 1988. [See Medline Record]

  36. Klabunde, RE, CC Hemenway, S Mohrman, J Henkin and SF Badylak. Optimizing the bolus/infusion ratio for intravenous administration of urokinase in anesthetized dogs. Thromb Res 50:857-864, 1988. [See Medline Record]

  37. Badylak, SF, E Poehlman, C Williams, RE Klabunde, J Turek and W Schoenlein. A simple canine model of arterial thrombosis with endothelial injury suitable for investigation of thrombolytic agents. J Pharmacol Meth 19:293-304, 1988. [See Medline Record]

  38. Klabunde, RE, MH Laughlin and RB Armstrong. Systemic adenosine deaminase administration does not reduce active hyperemia in running rats. J Appl Physiol 64:108-114, 1988. [See Medline Record]

  39. Klabunde RE. Effects of adenosine on sympathetic vasoconstriction in dog gracilis muscle. J Pharmacol Exp Ther 240:106-110, 1987. [See Medline Record]

  40. Klabunde, RE. Attenuation of reactive and active hyperemia by sympathetic stimulation in dog gracilis muscle. Am J Physiol 251:H1183-H1187, 1986. [See Medline Record]

  41. Klabunde, RE. Conditions for dipyridamole potentiation of skeletal muscle active hyperemia. Am J Physiol 250:H62-H67, 1986. [See Medline Record]

  42. Rankin, RS and RE Klabunde. Indomethacin and meclofenamate potentiation of postcontraction hyperemia. Life Sci 36:161-168, 1985. [See Medline Record]

  43. Klabunde, RE and DE McDowell. A hydrodynamic model of the human leg circulation. The Physiologist 27:431-434, 1984. [See Medline Record]

  44. Kille, JM and RE Klabunde. Adenosine as a mediator of postcontraction hyperemia in dog gracilis muscle. Am J Physiol 246:H274-H282, 1984. [See Medline Record]

  45. Klabunde, RE. Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol 93:21-26, 1983. [See Medline Record]

  46. Klabunde, RE. Effects of dipyridamole on postischemic vasodilation and extracellular adenosine. Am J Physiol 244:H273-H280, 1983. [See Medline Record]

  47. Klabunde, RE and DG Althouse. Adenosine metabolism in dog whole blood: Effects of dipyridamole. Life Sci 28:2631-2641, 1981. [See Medline Record]

  48. Klabunde, RE and PC Johnson. Effects of reduced temperature on capillary flow and reactive hyperemia in red and white skeletal muscle. Microvasc Res 19:99-107, 1980. [See Medline Record]

  49. Klabunde, RE and SE Mayer. Effects of ischemia on tissue metabolites in red (slow) and white (fast) skeletal muscle of the chicken. Circ Res 45:366-373, 1979. [See Medline Record]

  50. Klabunde, RE, CL Winser, CS Ito and SE Mayer. Measurement of adenosine and inosine in heart samples by high pressure liquid chromatography. J Molec Cell Cardiol 11:707-715, 1979. [See Medline Record]

  51. Klabunde, RE and PC Johnson. Capillary velocity and tissue PO2 changes during reactive hyperemia in skeletal muscle. Am J Physiol 233:H379-H383, 1977. [See Medline Record]

  52. Klabunde, RE and PC Johnson. Reactive hyperemia in capillaries of red and white skeletal muscle. Am J Physiol 232:H411-H417, 1977. [See Medline Record]

   
   
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Heritage College of Osteopathic Medicine
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Last updated: 02/08/2012