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Selected Publications
Sackmann-Sala L, Ding J,
Frohman LA, Kopchick JJ. Activation of the GH/IGF-1
axis by CJC-1295, a long-acting GHRH analog, results
in serum protein profile changes in normal adult
subjects.Growth Horm IGF Res. 2009 Apr 20.
[Epub ahead of print]
PMID:
19386527 [PubMed - as supplied by publisher]
Izzard AS, Emerson M, Prehar S, Neyses L, Trainer P,
List EO, Kopchick JJ, Heagerty AM. The
cardiovascular phenotype of a mouse model of
acromegaly. Growth Horm IGF Res. 2009 Mar 6.
[Epub ahead of print]
PMID:
19269870 [PubMed - as supplied by publisher]
Bonkowski MS, Dominici FP, Arum O, Rocha JS, Al
Regaiey KA, Westbrook R, Spong A, Panici J,
Masternak MM, Kopchick JJ, Bartke A.
Disruption of growth hormone receptor prevents
calorie restriction from improving insulin action
and longevity. PLoS ONE. 2009;4(2):e4567. Epub 2009
Feb 23.
PMID:
19234595 [PubMed - indexed for MEDLINE]
Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb
CR, Berryman DE, List EO, Kopchick JJ, Bartke
A. Reduced incidence and delayed occurrence of fatal
neoplastic diseases in growth hormone
receptor/binding protein knockout mice.
J Gerontol A Biol Sci Med Sci. 2009 May;64(5):522-9.
Epub 2009 Feb 19.
PMID:
19228785 [PubMed - in process]
Melmed S, Colao A, Barkan A, Molitch M, Grossman AB,
Kleinberg D, Clemmons D, Chanson P, Laws E,
Schlechte J, Vance ML, Ho K, Giustina A; Acromegaly
Consensus Group. Guidelines for acromegaly
management: an update.J Clin Endocrinol Metab. 2009
May;94(5):1509-17.
Epub 2009 Feb 10.
PMID:
19208732 [PubMed - in process]
Bartke A, Kopchick J. Comment on: Kloting et
al. (2008) Autocrine IGF-1 action in adipocytes
controls systemic IGF-1 concentrations and growth:
Diabetes 57:2074-2082. Diabetes. 2009 Jan;58(1):e3;
author reply e4. No abstract available.
PMID:
19114718
[PubMed - indexed for MEDLINE]
Kraemer WJ, Vingren JL, Schuenke MD, Kopchick JJ,
Volek JS, Fragala MS, Häkkinen K, Jen-Ho, Thomas GA,
Staron RS. Effect of circulating growth hormone on
muscle IGF-I protein concentration in female mice
with growth hormone receptor gene disruption.Growth
Horm IGF Res. 2008 Dec 9.
[Epub ahead of print]
PMID:
19083250 [PubMed - as supplied by publisher]
Stevenson AE, Evans BA, Gevers EF, Elford C, McLeod
RW, Perry MJ, El-Kasti MM, Coschigano KT,
Kopchick JJ, Evans SL, Wells T. Does adiposity
status influence femoral cortical strength in rodent
models of growth hormone deficiency?
Am J Physiol Endocrinol Metab. 2009
Jan;296(1):E147-56.
Epub 2008 Nov 11.
PMID:
19001545 [PubMed - indexed for MEDLINE]
Nass R, Johannsson G, Christiansen JS, Kopchick
JJ, Thorner MO. The aging population--is there a
role for endocrine interventions? Growth Horm IGF
Res. 2009 Apr;19(2):89-100.
Epub 2008 Nov 1.
PMID:
18977675 [PubMed - in process]
Palmer AJ, Chung MY, List EO, Walker J, Okada S,
Kopchick JJ, Berryman DE.
Age-related changes in body composition of bovine
growth hormone transgenic mice. Endocrinology. 2009
Mar;150(3):1353-60.
Epub 2008 Oct 23.
PMID:
18948397 [PubMed - indexed for MEDLINE]
Berryman DE, Christiansen JS, Johannsson G, Thorner
MO, Kopchick JJ. Role of the GH/IGF-1 axis in
lifespan and healthspan: lessons from animal models.
Growth Horm IGF Res. 2008 Dec;18(6):455-71.
Epub 2008 Aug 16.
PMID:
18710818 [PubMed - in process]
Schuenke MD, Kopchick JJ, Hikida RS, Kraemer
WJ, Staron RS. Effects of growth hormone
overexpression vs. growth hormone receptor gene
disruption on mouse hindlimb muscle fiber type
composition. Growth Horm IGF Res. 2008
Dec;18(6):479-86.
Epub 2008 May 21.
PMID:
18499495 [PubMed - in process]
List EO, Berryman DE, Bower B, Sackmann-Sala L,
Gosney E, Ding J, Okada S, Kopchick JJ. The
use of proteomics to study infectious diseases.
Infect Disord Drug Targets. 2008 Mar;8(1):31-45.
Review.
PMID:
18473905 [PubMed - indexed for MEDLINE]
Baudet ML, Hassanali Z, Sawicki G, List EO,
Kopchick JJ, Harvey S. Growth hormone action in
the developing neural retina: a proteomic analysis.
Proteomics. 2008 Jan;8(2):389-401.
PMID:
18203262 [PubMed - indexed for MEDLINE]
Berryman DE, Palmer AJ,
Gosney ES, Swaminathan S, DeSantis D, Kopchick JJ.
Discovery and uses of pegvisomant: a growth hormone
antagonist. Endokrynol Pol. 2007; 58(4):322-9.
Swanson SM, Kopchick JJ. Nuclear localization
of growth hormone receptor: another age of discovery
for cytokine action? Sci. 2007; 415, 69.
Chandrashekar V, Dawson CR, Martin ER, Rocha JS,
Bartke A, Kopchick JJ. Age-related
alterations in pituitary and testicular functions in
long-lived growth hormone receptor gene-disrupted
mice. Endocrinology. 2007; 148(12):6019-25.
Shao R, Egecioglu E, Weijdegård B, Kopchick JJ,
Fernandez-Rodriguez J, Andersson N, Billig H.
Dynamic regulation of estrogen receptor-alpha
isoform expression in the mouse fallopian tube:
mechanistic insight into estrogen-dependent
production and secretion of insulin-like growth
factors. Am J Physiol Endocrinol Metab. 2007;
293(5):E1430-42.
Kelder B, Berryman DE, Clark R, Li A, List EO,
Kopchick JJ. CIDE-A gene expression is decreased
in white adipose tissue of growth hormone
receptor/binding protein gene disrupted mice and
with high-fat feeding of normal mice. Growth Horm
IGF Res. 2007; 17(4):346-51.
Kelder B, Boyce K, Kriete A, Clark R, Berryman DE,
Nagatomi S, List EO, Braughler M, Kopchick JJ.
CIDE-A is expressed in liver of old mice and in type
2 diabetic mouse liver exhibiting steatosis. Comp
Hepatol. 2007; 1;6:4.
Smid JR, Rowland JE, Young WG, Coschigano KT,
Kopchick JJ, Waters MJ. Mouse molar dentin
size/shape is dependent on growth hormone status. J
Dent Res. 2007; 86(5):463-8.
del Rincon JP, Iida K, Gaylinn BD, McCurdy CE,
Leitner JW, Barbour LA, Kopchick JJ, Friedman
JE, Draznin B, Thorner MO. Growth hormone regulation
of p85alpha expression and phosphoinositide 3-kinase
activity in adipose tissue: mechanism for growth
hormone-mediated insulin resistance. Diabetes. 2007;
56(6):1638-46.
Egecioglu E, Andersson IJ, Bollano E, Palsdottir V,
Gabrielsson BG, Kopchick JJ, Skott O, Bie P,
Isgaard J, Bohlooly-Y M, Bergström G, Wickman A.
Growth hormone receptor deficiency in mice results
in reduced systolic blood pressure and plasma renin,
increased aortic eNOS expression, and altered
cardiovascular structure and function. Am J Physiol
Endocrinol Metab. 2007; 292(5):E1418-25.
Al-Regaiey KA, Masternak MM, Bonkowski MS, Panici
JA, Kopchick JJ, Bartke A. Effects of caloric
restriction and growth hormone resistance on
insulin-related intermediates in the skeletal
muscle. J Gerontol A Biol Sci Med Sci. 2007;
62(1):18-26.
Reddy GR, Pushpanathan MJ, Ransom RF, Holzman LB,
Brosius FC 3rd, Diakonova M, Mathieson P, Saleem MA,
List EO, Kopchick JJ, Frank SJ, Menon RK.
Identification of the glomerular podocyte as a
target for growth hormone action. Endocrinology.
2007; 148(5):2045-55.
Kopchick, J.J., Bartke, A., Berryman, D.E.,
Extended lifespan in mice with reduction in the GH/IGF-1
Axis. The Mol. Biol. of Aging, 1st Edition, Cold
Spring Harbor Laboratory Press (in press), 2007.
Venken K, Movérare-Skrtic S, Kopchick JJ,
Coschigano KT, Ohlsson C, Boonen S, Bouillon R,
Vanderschueren D. Impact of androgens, growth
hormone, and IGF-I on bone and muscle in male mice
during puberty. J Bone Miner Res. 2007; 22(1):72-82.
Flint DJ, Binart N, Boumard S, Kopchick JJ,
Kelly P. Developmental aspects of adipose tissue in
GH receptor and prolactin receptor gene disrupted
mice: site-specific effects upon proliferation,
differentiation and hormone sensitivity. J
Endocrinol. 2006; 191(1):101-11.
Sotiropoulos A, Ohanna M, Kedzia C, Menon RK,
Kopchick JJ, Kelly PA, Pende M. Growth hormone
promotes skeletal muscle cell fusion independent of
insulin-like growth factor 1 up-regulation. Proc
Natl Acad Sci USA. 2006; 9;103(19):7315-20.
Manhès C, Kayser C, Bertheau P, Kelder B,
Kopchick JJ, Kelly PA, Touraine P, Goffin V.
Local over-expression of prolactin in
differentiating mouse mammary gland induces
functional defects and benign lesions, but no
carcinoma. J Endocrinol. 2006; 190(2):271-85.
Robertson K, Kopchick JJ, Liu JL. Growth
hormone receptor gene deficiency causes delayed
insulin responsiveness in skeletal muscles without
affecting compensatory islet cell overgrowth in
obese mice. Am J Physiol Endocrinol Metab. 2006;
291(3):E491-8.
Berryman DE, List EO, Kohn DT, Coschigano KT, Seeley
RJ, Kopchick JJ. Effect of growth hormone on
susceptibility to diet-induced obesity.
Endocrinology. 2006; 147(6):2801-8.
Tiong, J.D.R., Gosney, E., Ding, J., Chin, E.,
Kopchick, J.J. A liver specific gene that is
expressed in growth hormone transgenic mice and in
normal female mice as a function of age. Growth
Hormone & IGF Research, 2006; 16:3:145-156.
Zhang, X., Mehta,R.G., Lantivit, D.D., Coschigano,
K.T., Kopchick, JJ., Green, J.E., Hedayat,
S., Christoy, K.T., Ray, V.H., Unterman, T.G. and
Swanson, S.M. Inhibition of estrogen independent
mammary carcinogenesis by disruption of growth
hormone signaling. Carcinogeneis, 2006;
28(1):143-150.
van der Lely, A.J. and Kopchick, J.J. Growth
hormone receptor antagonists. Neuroendo. 2006;
83(3-4):264-268.
Salmon, A.B., Murakami, S., Bartke, A., Kopchick,
J.J., Yasumura, K. and Miller, R.A. Fibroblast
cell lines from young adult mice of long-lived
mutant strains are resistant to multiple forms of
stress. Am. J. Physiol. Endo. Metab. 2005;
289:E23-E29.
Boyce, K., Kriete, A., Nagatomi, S., Kelder, B.,
Coschigano, K. and Kopchick, J.J.
Phenotypical enrichment strategies for micro-array
data analysis applied in a type II diabetes study.
OMICS, 2005; 9(3):251-265.
Kopchick, J.J., Growth Hormone,
Endocrinology, DeGroot and Jameson, 5th Edition,
Vol. 1, Chapter 32, p. 579-599, 2005.
Nilsson L, Binart N, Bohlooly-Y M, Bramnert M,
Egecioglu E, Kindblom J, Kelly PA, Kopchick JJ,
Ormandy CJ, Ling C, Billig H. Prolactin and growth
hormone regulate adiponectin secretion and receptor
expression in adipose tissue. Biochem Biophys Res
Commun. 2005; 17;331(4):1120-6.
Guo Y, Lu Y, Houle D, Robertson K, Tang Z,
Kopchick JJ, Liu YL, Liu JL. Pancreatic
islet-specific expression of an insulin-like growth
factor-I transgene compensates islet cell growth in
growth hormone receptor gene-deficient mice.
Endocrinology. 2005; 146(6):2602-9.
Wang Z, Prins GS, Coschigano KT, Kopchick JJ,
Green JE, Ray VH, Hedayat S, Christov KT, Unterman
TG, Swanson SM. Disruption of growth hormone
signaling retards early stages of prostate
carcinogenesis in the C3(1)/T antigen mouse.
Endocrinology. 2005; 146(12):5188-96.
Stauber AJ, Brown-Borg H, Liu J, Waalkes MP,
Laughter A, Staben RA, Coley JC, Swanson C, Voss KA,
Kopchick JJ, Corton JC. Constitutive
expression of peroxisome proliferator-activated
receptor alpha-regulated genes in dwarf mice. Mol
Pharmacol. 2005; 67(3):681-94.
List, E.O., Berryman, D.E., Palmer, A.J., Qiu, L.,
Sankaran, S., Kohn, D.T., Kelder, B., Okada, S. and
Kopchick, J.J. Analysis of mouse skin reveals
proteins that are altered ina diet-induced diabetic
state: A new method for detection of type 2
diabetes. Proteomics. 2007; 7(7):1140-1149.
Kopchick, J.J., Sackmann-Salsa, L. and Ding,
J. Molecular tools for the understanding of
molecular endocrinology. Nature Clinical Practice,
Endo & Met. 2007; 3(4) 355-368.
Qiu, L., List, E.O. and Kopchick, J.J.
Differentially expressed proteins in the pancreas of
diet-induced mice. Mol. Cell Proteomics. 2005;
4(9):1311-1318.
Maamra, M., Kopchick, J.J., Strasburger, C.J. and
Ross, R.J.M. Pegvisomant, a growth hormone specific
antagonist, undergoes cellular internalization. J.
Clinical Endocrinology and Metabolism, 2004,
89(9):4532-4537. [See
Medline Record]
Bartke, A., Peluso, M.R., Moretz, N., Wright, C.,
Bonkowski, M., Winters, T.A., Shanahan, M.F.,
Kopchick, J.J., Banz, W.J. Effects of Soy-derived
diets on plasma and liver lipids, glucose tolerance,
and longevity in normal, long-lived and short-lived
mice. Horm. Metab. Res. 2004, 36(8):550-558. [See
Medline Record]
Young, W.G., Ramirez-Yanez, G.O., Daley, T.J., Smid,
J.R., Coschigano, K.T., Kopchick, J.J. and Waters, M.J. Growth hormone epidermal growth factor in
salivary glands of giant and dwarf transgenic mice.
J. Histochemistry & Cytochemistry, 2004,
52(9):1191-1197. [See
Medline Record]
Iida, K., Itoh, E., Kim, D.S., del Rincon, J.P.,
Coschigano, K.T., Kopchick, J.J. and Thorner, M.O.
Muscle mechano growth factor is preferentially
induced by growth hormone (GH) and GH deficient
lit/lit mice. J. Phys., 2004. 15:560LPt 2):341-349.
[See
Medline Record]
Nass,
R., Liu, J., Hellmann, P., Coschigano, K.T., Gaylinn,
B., Berryman, D.E. , Kopchick, J.J., Thorner, M.O.
Chronic changes in peripheral growth hormone levels
do not affect ghrelin stomach mRNA expression and
serum ghrelin levels in three transgenic mouse
models. J. Neuroendocrinology, 2004, 16(8):669-675.
[See
Medline Record]
Pennisi, P.A., Kopchick, J., Thorgeirsson, S.,
LeRoith, D. and Yakar, S. Role of growth hormone
(GH) in liver regeneration. Endocrinology, 2004,
145(10):4748-4755.[See
Medline Record]
Berryman, D.E., List, E.O., Coschigano, K.T., Behar,
K., Kim, Jason, K. and Kopchick, J.J. Comparing
adiposity profiles in three mouse models. Growth
Hormone & IGF Research, 2004, 14:309-318. [See
Medline Record]
Iida, K., Del Rincon, J.P., Kim, D.S., Itoh, E.,
Coschigano, K.T., Kopchick, J.J. and Thorner, M.O.
Regulation of full-length and truncated growth
hormone (GH) receptor by GH in tissues of lit/lit or
bovine GH transgenic mice. Am. J. Physiol. Endo.
Metab., 2004, 287:E566-E573. [See
Medline Record]
Liu,
J.L., Coschigano, K.T., Robertson, K., Lipsett, M.,
Guo, Y., Kopchick, J.J., Kumar,U., and Liu, Y.L.
Disruption of growth hormone receptor gene causes
diminished pancreatic islet size and increased
insulin sensitivity in mice. Am. J. Physiol. Endo.
Metab., 2004, 287:E405-413. [See
Medline Record]
Muller, A.F., Kopchick, J.J., Flyvbjer, A and van
der Lely, A.J. Growth Hormone Receptor
Antagonists. Clinical Review 166, Clinical
Endocrinology & Metabolism, 2004, 89(4):1503. [See
Medline Record]
Mellwain, D.L., Hoke, V.B., Kopchick, J.J., Fuller,
C.R. and Lund, P.K. Differential inhibition of
postnatal brain, spinal cord and body growth by a
growth hormone antagonist. Neuroscience, 2004,
23:5(1):6. [See
Medline Record]
Wang, J., Zhou, J., Cheng, C.M., Kopchick, J.J. and Bondy, C.A. Evidence supporting dual,
Igf1-independent and Igf1-dependent, roles for GH in
promoting longitudinal bone growth. Journal of
Endocrinology, 2004, 180:247-255. [See
Medline Record]
Iida, K., del Rincon, J.P., Kim, D.S., Itoh, E.,
Nass, R., Coschigano, K.T., Kopchick, J.J. and Thorner, M.O. Tissue-specific regulation of growth
hormone (GH) receptor and insulin-like growth
factor-I gene expression in the pituitary and liver
of GH deficient (lit/lit) mice and ransgenic mice
that overexpress bGH or a bGH antagonist.
Endocrinology, 2004, 145:1564-1570. [See
Medline Record]
Flint, D.J., Binart, N., Kopchick, J.J. Kelly P.
Effects of growth hormone and prolactin on adipose
tissue development and function. Pituitary, 2003,
6(2):97-102, review. [See
Medline Record]
Yakar, S., Setser, J., Zhao, H., Stannard, B.,
Haluzik, M., Glatt, V., Bouxsein, M.L., Kopchick,
J.J. and LeRoith, D. Inhibition of growth hormone
action improves insulin sensitivity in liver
IGF-1-deficient mice. J. Clin. Invest., 2004,
113:96-105. [See
Medline Record]
Smid, J. R., Rowland, J. E., Young, W. G., Daley, T.
J., Coschigano, K. T., Kopchick, J. J., and Waters,
M. J. Mouse cellular cementum is highly dependent on
growth hormone status. J Dent Res., 2004,
83(1):35-39. [See
Medline Record]
Yakar, S., Setser, J., Zhao, H., Stannard, B.,
Haluzik, M., Glatt, V., Bouxsein, M. L., Kopchick,
J. J., and LeRoith, D. Inhibition of growth hormone
action improves insulin sensitivity in liver
IGF-1-deficient mice. J Clin Invest. 2004.113,
96-105. [See Medline Record]
Wang, J., Zhou, J., Cheng, C. M., Kopchick, J. J.,
and Bondy, C. A. Evidence supporting dual,
IGF-I-independent and IGF-I-dependent, roles for GH
in promoting longitudinal bone growth. J
Endocrinology, 2004, 180, 247-255. [See Medline
Record]
Kopchick, J.J. Pegvisomant: A new drug entity for
acromegaly. MIMS Advances, May 2004. [See Medline
Record]
Keiji, I., del Rincon, J.P., Kim, D.S., Itoh, E.,
Coschigano, K.T., Kopchick, J.J. and Thorner, M.O.
Regulation of full-length and truncated growth
hormone (GH) receptor by GH in tissues of lit/lit or
bovine GH transgenic mice. Am. Jour. Physiol.,
Endo. Metab., 2004. [See Medline Record]
Smid, J.R., Rowland, J.E., Young, W.G., Daley, T.J.,
Coschigano, K.T., Kopchick, J.J. and Waters, M.J.
Mouse cellular cementum is highly dependent on
growth hormone status. J. Dent. Res., 2004,
83(1):35-39. [See Medline Record]
Nass, R., Liu, J., Hellman, P., Coschigano, K.T.,
Gaylinn, B., Berryman, D.E., Kopchick, J.J. and Thorner, M.O. Chronic changes in peripheral growth
hormone levels do not affect ghrelin stomach mRNA
expression and serum chrelin levels in three
transgenic mouse models”. J. of Neuroendocrinology,
2004, 16:669-675. [See Medline Record]
Young, W.G., Ramirez-Yanez, G.O., Daley, T.J., Smid,
J.R., Coschigano, K.T., Kopchick, J.J. and Waters, M.J. Growth hormone and epidermal growth factor in
salivary glands of giant and dwarf transgenic mice.
J. Histochem. Cytochem, 2004, 52:1191-1197. [See
Medline Record]
Kopchick, J.J. History and future of growth hormone
research. Horm. Res. 2003:60 Suppl. 3:103-112,
review. [See
Medline Record]
Coschigano, K.T., Holland, A.N., Riders, M.E., List,
E.O., Flyvbjerg, A., Kopchick, J.J. Deletion, but
not antagonism, of the mouse growth hormone receptor
results in severely decreased body weights, insulin
and IGF-1 levels and increased lifespan.
Endocrinology, 2003, 144(9):3799-3810. [See
Medline Record]
Bernichtein, S., Kayser, C., Dillner, K., Moulin,
S., Kopchick, J.J., Martial, J.A., Norstedt, G.,
Isaksson, O., Kelly, P.A., Goffin, V. Development
of pure prolactin receptor antagonists. Journal of
Biological Chemistry, 2003, 278:38:35988-35999. [See
Medline Record]
Kopchick, J.J. Discovery and mechanism of action of pegvisomant. Society of the European Journal of
Endocrinology, 2003, 148:Suppl 2:S21-S. [See
Medline Record]
Parsons, S.A., Banks, G.B., Rowland, J.A.,
Coschigano, K.T., Kopchick, J.J., Waters, M.J. and
Noakes, P.G. Genetic disruption of the growth
hormone receptor does not influence motoneuron
survival in the developing mouse. Int. J. Devl.
Biol., 2003. 47:41-49. [See
Medline Record]
Bartke, A., Chandrashekar, V., Dominici, F., turyn,
D., Kinney, B., Steger, R., Kopchick, J.J.
Insulin-like growth factor 1 (IGF-1) and aging:
controversies and new insights. Biogerontology,
2003, 4(1):1-8. [See
Medline Record]
Li,
Y., Knapp, J.R., and Kopchick, J.J. Enlargement of interscapular brown adipose tissue in growth hormone
antagonist transgenic and in growth hormone receptor
gene-disrupted dwarf mice. Society for Experimental
Biology and Medicine, 2003, 207-215. [See
Medline Record]
Bartke, A., Kopchick, J.J., Dominici, F., Turyn, D.
IGF-1 and insulin signaling in the control of
longevity. Book: Endocrine Aspects of Successful
Aging: Genes, Hormones and Lifestyles, 2003, 19-33.
[See Medline Record]
Kopchick, J.J. History and future of growth hormone
research. Horm. Res., 2003, 60, Suppl. 3, 103-112.
[See Medline Record]
Li,
Y., Knapp, J.R. and Kopchick, J.J. Enlargement of interscapular brown adipose tissue in growth hormone
antagonist transgenic and in growth hormone receptor
gene-disrupted dwarf mice. Exp. Biol. Med. (Maywood)
2203, 228, 207-215. [See Medline Record]
Higashimori, T., Kim, H.J., Coschigano, K.T., Park,
S.Y., Choi, H., Kopchick, J.J., Shulman, G.I., and
Kim, J.K. Transgenic mice overexpressing growth
hormone are insulin resistant due to decreased
insulin-stimulated glucose uptake in skeletal muscle
and adipose tissue. Paper presented at American
Diabetes Association 63rd Scientific
Sessions (New Orleans, LA). 2003. [See Medline
Record]
Kohn, D.T. and Kopchick, J.J. Growth hormone
receptor antagonists. Minerva Endocrinologica, 2002,
27:4:287-298. [See
Medline Record]
Kelly, P.A., Bachelot,A., Kedzia, C., Hennighausen,
L., Ormandy, C.J., Kopchick, J.J., Binart, N. The
role of prolactin and growth hormone in mammary
gland development. Molecular & Cellular
Endocrinology, 2002, 197:1-2, 127-131. [See
Medline Record]
Miller, R.A., Chang, Y., Galecki, A.T., Al-Regaiey,
K., Kopchick, J.J. and Bartke, A. Gene expression
patterns in calorically restricted mice: partial
overlap with long-lived mutant mice. Molecular
Endocrinology, 2002, 16(11):2657-2666. [See
Medline Record]
Hauck, S.J., Aaron, J.M, Wright, C., Kopchick, J.J.
and Bartke, A. Antioxidant Enzymes, free-radical
damage, and response to paraquat in liver and kidney
of long-living growth hormone receptor/binding
protein gene-disrupted mice. Hormone and Metabolic
Research, 2002, 34:481-486. [See
Medline Record]
Kopchick, J.J., Parkinson, C., Stevens, E.C. and
Trainer, P.J. Growth hormone receptor antagonists:
discovery, development, and use in patients with
acromegaly. Endocrine Reviews, 2002, 23:5:623-646. [See
Medline Record]
Leonard, A.E., Kelder, B., Bobik, E.G., Chuang,
L.T., Lewis, C.J., Kopchick, J.J., Mukerji, P. and
Huang, Y.S. Identification and expression of
mammalian long-chain PUFA elongation enzymes.
Lipids, 2002, 37(8):733-740. [See
Medline Record]
Zaczek, D., Hammond, J., Suen, L., Wandji, S.,
Service, D., Bartke, A., Chandrashekar, V.,
Coschigano, K. and Kopchick, J.J. Impact of growth
hormone Resistance on female reproductive function:
New insights from growth hormone receptor knockout
mice. Biology of Reproduction, 2002, 67:1115-1124.
[See
Medline Record]
Bachelot, A., Monget, P., Imbert-Bollore, P.,
Coschigano, K., Kopchick, J.J., Kelly, P.A. and Binart, N. Growth hormone is required for ovarian
follicular growth. Endocrinology, 2002, 143,
4104-4112. [See
Medline Record]
Keene, D.E., Suescun, M.O., Bostwick, M.G.,
Chandrashekar, V., Bartke, A. and Kopchick, J.
Puberty is delayed in male growth hormone receptor
gene disrupted mice. Journal of Andrology, 2002,
23:661-668. [See
Medline Record]
Kopchick, J.J., List, E.O., Kohn, D.T., Keidan,
G.M.O., Qiu, L. and Okada, S. Perspective:
Proteomics – See “Spots” Run. Endocrinology, 2002,
143(6):1990-1004. [See
Medline Record]
Kopchick, J.J. In vitro mutagenesis of the Growth
Hormone Gene. GH and Growth Factors, Current
Medical Literature, 2002, 17: 27-32. [See Medline
Record]
Bachelot, A., Monget, P., Imbert-Bollore, P.,
Coschigano, Kopchick, J.J., Kelly, P.A. and Binart,
N. Growth hormone is required for ovarian
follicular growth. Endocrinology, 2002,
13:4104-4112. [See Medline Record]
Kelder, B., Erney, R., Kopchick, J., Cummings, R.
and Pieto, P. Glycoconjugates in Human and
Transgenic Animal Milk. Bioactive Components of
Human Milk, edited by Newburg. Kluwer
Academic/Plenum Publishers, New York, 2001, pp.
6269-278. [See
Medline Record]
Kopchick, J.J. and Okada, S. Review Article: Growth
hormone receptor antagonists: discovery and
potential uses. Growth Hormone & IGF Research, 2001,
Supplement A, S103-109. [See
Medline Record]
Kineman, R.D., Teixeira, L.T., Amargo, G.V.,
Coschigano, K.T., Kopchick, J.J. and Frohman, L.A.
The effect of GHRH on somatotrope hyperplasia and
tumor formation in the presence and absence of GH
signaling. Endo., 2001, 142:3764-3773. [See
Medline Record]
Doi,
S.Q., Rasaiah, S., Tack, I., Mysore, J., Kopchick,
J.J., Moore, J., Hirszel, P., Striker, L.J. and
Striker, G.E. Low-Protein diet suppresses serum
insulin-like growth facor-1 and decelerates the
progression of growth hormone-induced
glomerulosclerosis. American Journal of Nephrology,
2001, 21:331-339. [See
Medline Record]
Bartke, A., Coschigano, K., Kopchick, J.J.,
Chandrashekar, V., Mattison, J., Kinney, B and
Hauck, S. Genes that prolong life. Effects of
growth hormone signaling on aging and life span.
Journal of Gerontology, Biological Sciences, 2001,
56A:8:B340-B349. [See
Medline Record]
Pollak, M., Blouin M.J., Zhang, J.C., and Kopchick,
J.J. Reduced mammary gland carcinogenesis in
transgenic mice expressing a growth hormone
antagonist. Br. J. Cancer, 2001, 85: 428-430. [See
Medline Record]
Turner, N.D., Knapp, J.R., Byers, F.M. and Kopchick,
J.J. Physical and mechanical characteristics of
tibias from transgenic mice expressing mutant bovine
growth hormone genes. Experimental Biology in
Medicine, 2001, 133-139. [See Medline Record]
Okada, S. and Kopchick, J.J. Biological effects of
growth hormone and its antagonist. Trends in
Molecular Medicine, 2001, 7:3:126-132. [See Medline
Record]
Smith, L.E., Kopchick, J.J., Chen, W. et.al.
Regulation of the effect of growth hormone in
retinal neovascularization by downstream effectors
IGF-1 and VEGF. Excerpta Medica Medical
Communications B.V., 2001, pp. 8-9. [See Medline
Record]
Peng, X., Park S., Gadelha, M.R., Coschigano, K.T.,
Kopchick, J.J., Frohman, L.A.and Kineman, R.D. The
GH-Axis of GHR/BP Gene-Disrupted (GHR/BP-/-) and
Metallothionein-Human GH-Releasing Hormone
(MT-hGHRH) Transgenic Mice: Hypothalamic
Neuropeptide and Pituitary Receptor Expression in
the Absence and Presence of GH Feedback.
Endocrinology, 2001, 142:3:1117-1123. [See Medline
Record]
List, E.O., Coschigano, K.T. and Kopchick, J.J.,
Mini-Review: Growth Hormone Receptor/Binding Protein
(GHR/BP) Knockout Mice: A 3-Year Update. Molecular
Genetics and Metabolism, 2001, 73:1-10. [See
Medline Record]
Hauck, S.J., Hunter, W.S., Danilovich, N., Kopchick,
J.J. and Bartke, A., Reduced Levels of Thyroid
Hormones, Insulin, and Glucose, and Lower Body Core
Temperature in the Growth Hormone Receptor/Binding
Protein Knockout Mouse. Society for Experimental
Biology and Medicine, 2001, pp. 552-558. [See
Medline Record]
Li,
Yunsheng, Kelder, Bruce, and Kopchick, J.J.,
Identification, Isolation, and Cloning of Growth
Hormone (GH)-Induced Interscapular Brown Adipose
Complementary Deoxyribonucleic Acid from GH
Antagonist Mice. Endocrinology, 2001,
142:2937-2945. [See Medline Record]
Chandrashekar, V., Bartke, A., Awoniyi, C.A.,
Tsai-Morris, C.H., Dufau, M.L., Russell, L.D. and
Kopchick, J.J., Testicular Endocrine Function in GH
Receptor Gene Disrupted Mice. Endocrinology, 2001,
142:8:3443-3450. [See Medline Record]
Kinney, B.A., Coschigano, K.T., Kopchick, J.J.,
Steger, R.W., Bartke, A. Evidence that age-induced
decline in memory retention is delayed in growth
hormone resistant GH-R-KO (Laron) mice. Physiology
& Behavior, 2001, 72:653-660. [See Medline Record]
Li, Z., Gu, T., Kelder, B., Kopchick
J.J.
Analysis of Fatty Acids in Mouse Cells Using
Reversed-Phase High-Performance Liquid
Chromatography. Chromatographia, 2001, 54:7/8. [See
Medline Record]
Kopchick, J.J. Mini Mice, Football and Dirty Shorts.
The Endocrinologist, 2001, No. 61, p.13. [See
Medline Record]
Bartke, A., Chandrashekar, V., Turyn, D., Steger,
R.W., Debeljuk, L, Winters, T.A., Mattison, J.A.,
Danilovich, N.A., Croson, W., Wernsing, D.R. and
Kopchick, J.J. MiniReview: Effects of Growth
Hormone Overexpression and Growth Hormone Resistance
on Neuroendocrine and Reproductive Functions in
Transgenic and Knock-Out Mice. Growth Hormone and
Reproduction, 2001, pp. 113-123. [See Medline
Record]
Gallego, M.I., Binart, N., Robinson, G.W., Okagaki,
R., Coschigano, K., Perry, J., Kopchick, J., Oka,
T., Kelly, P.A. and Hennighausen, L. Prolactin
growth hormone and epidermal growth factor activate
Stat 5 in different compartments of mammary tissue
and exert different and overlapping developmental
effects. Developmental Biology, 2001, 229: 163-175.
[See Medline Record]
Zhang, Y., Guan, R., Jiang, J., Kopchick, J.J.,
Black, R.A., Baumann, G. and Frank, S.J. Growth
hormone-induced dimerization inhibits phorbol
ester-stimulated GH receptor proteolysis. J. Biol.
Chem., 2001, 267:24565-24573. [See Medline Record]
Kopchick, J.J., Okada, S., Coschigano, K.T. Lessons
from growth hormone (GH) antagonist and GH receptor
“knockout” mice, in Targets for growth hormone and
IGF-1 action. R. Bouillon, Editor, Bioscientifica
Ltd.: Bristol, 2001, 1-26. [See Medline Record]
Chandrashekar, V., Coschigano, K.T., Bartke, A. and
Kopchick, J.J. Neuroendocrine and reproductive
functions in transgenic mice with altered growth
hormone secretion and in growth hormone receptor
gene disrupted mice. In “Transgenic Models in
Endocrinology”. Editor: Dr. M.G. Castro, Kluwer
Academic Publishers, Boston, 2001. [See Medline
Record]
Bartke, A., Coschigano, K.T., Kopchick, J.J.,
Chandrashekar, V., Mattison, J., Kinney, B., and
Hauck, S. Genes that prolong life: relationships of
growth hormone and growth to aging and life span.
J. Gerontol. A. Biol. Sci., med. Sci., 2001,
56:B340-349. [See Medline Record]
Chen, W.Y., Wight,
D., Chen, N.Y., Wagner, T., and Kopchick, J.J.:
Mutations in the third alpha-helix of bovine growth
hormone dramatically effects growth hormone
secretion in vitro and growth
enhancement in transgenic mice. JBC,
266:2252-2258, 1991.
[See Medline Record]
Chen, W.Y., White,
M.E., Wagner, T.E. and Kopchick, J.J.:
Functional antagonism between endogenous mouse
growth hormone (GH) and a GH analog results in
transgenic dwarf mice. Endo., 129:1402-1408,
1991.
[See Medline Record]
Chen, W.Y., Wight,
D.C., Mehta, B.V., Wagner, T.E. and Kopchick, J.J.:
Glycine 119 of bovine growth hormone is critical for
growth promoting activity. Mol. Endo.,
5:1845-1852, 1991.
[See Medline Record]
McAndrew, S.J.,
Wiehl, P., Chen, N.Y., DiCaprio, L., Yun, J.,
Wagner, T. and Kopchick, J.J.: Expression of
truncated forms of bovine growth hormone gene in
cultured mouse cells. JBC, 266:20965-20965,
1991.
[See Medline Record]
Chen, X.Z.,
Shafer, A.W., Yun, J.S., Li, Y.S., Wagner, T.E. and
Kopchick, J.J.: Conversion of bovine growth
hormone cysteine residues to serines affects
secretion by cultured cells and growth rates in
transgenic mice. Mol. Endo., 6(4):598-606,
1992.
[See Medline Record]
Okada, S., Chen,
W.Y., Wiehl, P., Kelder, B., Goodman, H.M., Guller,
S. Sonenberg, M. and Kopchick, J.J.: A growth
hormone (GH) analog can antagonize the ability of
native GH to promote differentiation of 3T3- F442A
preadipocytes and to stimulate insulin-like and
lipolytic activities in primary rat adipocytes.
Endo., 130(4):2284-2290, 1992.
[See Medline Record]
Wang, X., Xu, B.,
Souza, S.C. and Kopchick, J.J.: Growth Hormone
(GH) induces tyrosine-phosphorylated proteins in
Mouse L cells which express recombinant GH
receptors. PNAS, 91:1391-1395, 1994.
[See Medline Record]
Chen, W.Y., Chen,
N.Y., Yun, J., Wagner, T.E. and Kopchick, J.J.:
In vitro and in vivo studies of antagonistic effects
of human growth hormone analogs. JBC,
269:15892-15897, 1994.
[See Medline Record]
Chen, N., Chen,
W., Bellush, L., Yang, Chih-Wei, Striker, L.J.,
Striker,G.E. and Kopchick, J.J.: Effects of
streptozotocin treatment in growth hormone (GH) and
GH antagonist transgenic mice. Endo., 136:2,
660-667, 1995.
[See Medline Record]
Chen, W., Chen,
N., Yun, J., Wight, D.C., Wang, X.Z., Wagner, T.E.
and Kopchick, J.J.: Amino acid residues in the
third alpha-helix of growth hormone involved in
growth promoting activity. Mol. Endo.,
9:3:292-302, 1995.
[See Medline Record]
Wang, X., Souza,
S.C., Kelder, B., Cioffi, J.A. and Kopchick, J.J.:
A 40-amino acid segment of the growth hormone
receptor cytoplasmic domain is essential for
GH-induced tyrosine-phosphorylated cytosolic
proteins. JBC, 270:11:6261-6266, 1995.
[See Medline Record]
Prieto, P.A.,
Mukerji, P., Kelder, B., Erney, R., Gonzalez, D.,
Yun, J.S., Smith, D.F., Moremen, K.W., Nardelli, C.,
Pierce, M., Li, Y., Chen, X., Wagner, T.E.,
Cummings, R.D. and Kopchick, J.J.: Remodeling of
mouse milk glycoconjugates by transgenic expression
of a human glycosyltransferase. JBC,
270:49:29515-29519, 1995.
Souza, S.C.,
Frick, G.P., Wang, X., Kopchick, J.J., Lobo, R.B.
and Goodman, H.M.: A single arginine residue
determines species specificity of the human growth
hormone receptor. PNAS, 92:4:959-963, 1995.
Harding, P.A.,
Wang, X., Okada, S., Chen, W.Y., Wan, W. and
Kopchick, J.J.: Growth hormone (GH) and a GH
antagonist promote GH receptor dimerization and
internalization. JBC, 271:12:6708-6712, 1996.
[See Medline Record]
Wang, X., Darus,
C. J. and Kopchick, J. J.: Identification of
growth hormone receptor (GHR) tyrosine residues
required for GHR phosphorylation, JAK2 activation,
Stat 5 phosphorylation. Mol. Endo.,
10:1249-1260, 1996.
[See Medline Record]
Chen, N.Y., Chen,
W.Y. and Kopchick, J.J.: A growth hormone
antagonist protects mice against streptozotocin
induced glomerulosclerosis even in the presence of
elevated levels of glucose and glycated hemoglobin.
Endo., 197:5163-5165, 1996.
[See Medline Record]
Xu, B., Wang, X.,
Darus, C.J. and Kopchick, J.J.: Growth hormone
promotes the association of transcription factor
STAT5 with the growth hormone receptor. JBC,
271:33:19768-19773, 1996.
[See Medline Record]
Chen, N., Chen, W.
and Kopchick J.J.:
Co-expression of a bovine growth hormone (GH) and a
human GH antagonist gene in transgenic mice.
Endo.,138:851-854,1997.
[See Medline Record]
Chen, N.Y., Chen,
W.Y. and Kopchick, J.J.: Liver and Kidney Growth
Hormone (GH) Receptors Are Regulated Differently in
Diabetic GH and GH Antagonist Transgenic Mice.
Endo., 138:5:1988-1994, 1997.
Yang, C.W.,
Striker, G.E., Chen, W.Y., Kopchick, J.J. and
Striker, L.J.: Differential Expression of
Glomerular Extracellular Matrix and Growth Factor
mRNA in Rapid and Slowly Progressive
Glomerulosclerosis: Studies in Mice Transgenic for
Native or Mutated Growth Hormone. Laboratory
Investigation, 76:4:467-476, 1997.
[See Medline Record]
Smith, L.E.H.,
Kopchick, J.J., Chen, W., Knapp, J., Kinose, F.,
Daley, D., Foley, E., Smith.R.G. and Schaeffer,
J.M.: Essential Role of Growth Hormone in
Ischemia-induced Retinal Neovascularization.
Science, 276:1706-1709, 1997.
[See Medline Record]
Zhou, Y., Xu,
B.C., Maheshwari, H.G., He, L., Reed, M.,
Lozykowski, M., Cataldo, L.A., Chen, N., Okada, S.,
Knapp, J.R., Wagner, T.E., Baumann, G. and Kopchick,
J.J.: A Mammalian Model for Laron Syndrome
Produced by Targeted Disruption of the Growth
Hormone Receptor/Binding Protein Gene. PNAS,
94:13215-13220, 1997.
[See Medline Record]
Kelder, B.,
Stavenezer, E. and Kopchick, J.J.: Production,
characterization and functional activities of v-ski
in cultured cells. Gene, 202:15-21, 1997.
[See Medline Record]
Kopchick, J.J.,
Chen, X.Z., Li, Y., Steger, R.W., Yun, J.S., Wagner,
T.E. and Bartke, A.: Differential in vivo
activities of bovine growth hormone analogs.
Transgenic Research, 7:61-71, 1998.
Flyvbjerg, A.,
Bennett, W.F., Rasch, R., Kopchick, J.J. and
Scarlett, J.A.: Inhibitory effect of a growth
hormone receptor antagonist (G120K-PEG) on renal
enlargement, glomerular hypertrophy, and urinary
albumin excretion in experimental diabetes in mice.
Diabetes, 40:377-382, 1999.
[See Medline Record]
Ruan, W.,
Powell-Braxton, L., Kopchick, J.J. and Kleinberg, D.L.: Evidence that insulin-like growth factor I
and growth hormone are required for prostate gland
development. Endocrinology, 140:5:1984-1989,
1999.
[See Medline Record]
Frohman, L.A.,
Kineman, R.D., Kamegai, J., Park, S., Teixeira, L.T.,
Coschigano, K.T., Kopchick, J.J. Secretagogues
and the Somatotrope: Signaling and Proliferation.
Recent Progress in Hormone Research, Vol. 55, (in
press), 1999.
Bellush, L.L.,
Doublier, S., Holland, A.N., Striker, L.J., Striker,
G.E. and Kopchick, J.J.Protection against
diabetes-induced nephropathy in growth hormone
receptor/binding protein gene-disrupted mice.Endocrinology,
141:1:163-168, 2000.
Coschigano, K.T.,
Clemmons, D., Bellush, L.L. and Kopchick, J.J.
Assessment of Growth Parameters and Life Span of GHR/BP
Gene-Disrupted Mice. Endocrinology,
141:2608-2613, 2000.
Chandrashekar, V.,
Bartke, A., Awoniyi, C.A., Tsai-Morris, C.H., Dufau,
M.L., Russell, L.D. and Kopchick, J.J.
Testicular Endocrine Function in GH Receptor Gene
Disrupted Mice. Endocrinology,
142(8):3443-3450, 2001.
Okada, S. and
Kopchick, J.J. Biological effects of growth
hormone and its antagonist. Trends in Molecular
Medicine, 7:3:126-132, 2001.
Li, Yunsheng,
Kelder, Bruce, and Kopchick, J.J.,
Identification, Isolation, and Cloning of Growth
Hormone (GH)-Induced Interscapular Brown Adipose
Complementary Deoxyribonucleic Acid from GH
Antagonist Mice. Endocrinology,
142:2937-2945,2001.
Selected Patents
Growth hormone
antagonists (5 total) US05350836 09/27/1994
Growth Hormone Antagonists
Glycosyltransferase (5 total) US05700671 12/23/1997
Methods of making transgenic animals producing
oligosaccharides and glycoproteins |
|
