Research: Understanding inflammation in the
pathogenesis of chronic diseases. Inflammation is
the principal response of the body to deal with
injuries and it plays a role in the pathogenesis of
The Wnt proteins are
a family of extracellular signaling molecules highly
conserved, involved in many biological processes
like cell adhesion, differentiation, and migration.
Recently Wnt has been described as playing role in
cancer and chronic inflammatory diseases.
My laboratory is
working in three different models (diseases) to
define the role of Wnt signaling pathway in the
pathogenesis of each of them.
The goal is to elucidate how inflammation is
involved in pathogenic mechanisms of
Recently, we described the expression of Wnt5a (a
member of this family), in murine and human
atherosclerotic lesions. Am J Physiol Heart Circ
Physiol 294:6; 2864-70, 2008
My current research
focus concerns the role of Wnt5a in the pathogenesis
Ramiro Malgor, Eric Dickerson, Ashani Weeraratna,
Slominski, Jacobo Wortsman, Norikazu Harii, Aimee D.
Kohn, Randall T. Moon, Frank Schwartz, Doug
Goetz,Leonard D Kohn, and Kelly D McCall.
Phenylmethimazole Decreases Toll-like Receptor 3 and
Non-Canonical Wnt5a Expression in Pancreatic Cancer
& Melanoma Together with Tumor Cell Growth &
Migration Accepted for publication in Clinical
Cancer Research March 2009.
Yuriy Slyvka, Sharon R, Inman, Ramiro Malgor,
Edwin J. Jackson, Jennifer Yee, Olusayo Oshogwemoh,
John Adame and Felicia V. Nowak. Protective Effects
of Antioxidant Fortified Diet on Renal Function and
Metabolic Profile in Obese Zucker Rat. Endocrine
35: 89-100, 2009.
Christman II M.A., Goetz D. J, Dickerson E., McCall
K.D., Lewis C.J, Benencia F., Silver M.J., Kohn L.D.,
and Malgor R. Wnt5a is Expressed in Murine
and Human Atherosclerotic Lesions Am J Physiol
Heart Circ Physiol 294: H2864-H2870, 2008.
Deosarkar S.P., Malgor R., Fu J., Kohn L.D.,
Hanes J., Goetz D.J. Polymeric Particles Conjugated
with a Ligand to VCAM-1 Exhibit Selective, Avid and
Focal Adhesion to Sites of Atherosclerosis.
Biotechnolgy and Bioengineering 9999:1-8, 2008.