Edwin Rowland, Ph.D.
Associate Professor Emeritus of Immunoparasitology
Department of Biomedical Sciences
rowland@ohiou.edu
317 Irvine Hall
740-593-2375
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DEPT. OF BIOMEDICAL SCIENCES
DEPT. OF BIOLOGICAL SCIENCES
MOLECULAR & CELLULAR BIOLOGY PROGRAM
EDISON BIOTECHNOLOGY INSTITUTE
COLLEGE OF OSTEOPATHIC MEDICINE
 
 
Publications:

Heise, E.R., Rowland, E., and Beatty, N. 1976. Antigen and Immune Complex Induced Suppression of Delayed Hypersensitivity. In: Reticuloendothelial System in Health and Disease: Immunologic and Pathologic Aspects (ed. H. Friedman, M. Escober, S. Reichard). Advances in Experimental Medicine and Biology, Vol. 73-b. Plenum Publishing Corp., New York.

Rowland, E.C. and Kuhn, R.E. 1978. Suppression of Cellular Responses in Mice During Trypanosoma cruzi Infections. Infection and Immunity 20:393-397.

Rowland, E.C. and Kuhn, R.E. 1978. Suppression of the Anamnestic Cellular Responses During Experimental American Trypanosomiasis. Journal of Parasitology 64:741-742.

Cunningham, D.S., Kuhn, R.E. and Rowland, E.C. 1979. Suppression of the Humoral Responses in Mice During Trypanosoma cruzi Infection. Infection and Immunity 22:155-160.

Rowland, E.C. and Sibley-Philips, S. 1984. Bone Marrow Eosinophil Levels in Trypanosoma cruzi Infected Mice. Journal of Parasitology. 70:819-820.

Rowland, E.C. and Ritter, D.M. 1984. Corpus Christi Strain Induced Protection to Trypanosoma cruzi Infection in C3H(He) Mice: Transfer of resistance to Brazil strain challenge with lymphocytes. Journal of Parasitology. 70:760-766.

Ritter, D.M. and Rowland, E.C. 1984. Corpus Christi Strain Induced Protection to Trypanosoma cruzi Infection in C3H(He) Mice: Effective dose, time, route, and number of vaccinations. Journal of Parasitology. 70:755-759.

Bhida, M., S. Patel, E. Rowland and D. Smith 1985. In Vitro Stimulation of Macrophage by Quadrol (N,N,N1, N1,-tetrakis (2-hydroxypropyl) ethylenediamine). J. Immunopharm. 7:303-312.

Rowland, E.C. and E.A. Masters. 1987. Trypanosoma cruzi Specific Antibody Response in Immunized C3H(He) Mice During Infection. Int. J. Parasitol., 17:1125-1129.

Rowland, E.C. and R.L. Lavy, 1987. Cardiac Histology of Mice with Experimental Chagas Disease. J. Parasitol. 73:240-241.

Rowland, E.C., K.R. Spears and T.S. McCormick. 1988. Relationship of Parasite Specific Antibodies and Heart Specific Autoantibodies in Mice Infected with Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz Suppl I. 83:367.

McCormick, T.S. and E.C. Rowland. 1989. Trypanosoma cruzi: Cross Reactive Anti-Heart Autoantibodies Produced During Infection. Experimental Parasitology 69:393-401.

Mikhail, K.S. and E.C. Rowland. 1990. Trypanosoma cruzi Antigen-Specific Response in Immunized Mice During Acute and Chronic Infection. Journal of Parasitology, 76:690-697.

Rosfjord, E.C., K.S. Mikhail, E.C. Rowland and M.R. Powell. 1990. Analysis of Antibody Cross-Reactivity in Experimental American Trypanosomiasis, Journal of Parastiology, 76:698-702.

Lozykowski, M., T. McCormick and E. Rowland. 1991 Coincidence of Cardiac Histopathology and Tissue Antibody in Mice During Acute and Chronic Trypanosoma cruzi Infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85:225-226.

Powell, M.R., E.C. Rowland and R.A. Sidner. 1991. Trypanosoma cruzi: Flow Cytometric Analysis of Lymphocyte Subsets in Susceptible and Protected C3H/He Mice. Experimental Parasitology 73:197-202.

Rowland, E.C., K.S. Mikhail and T.S. McCormick. 1992. Isotype determination of anti-Trypanosoma cruzi antibody in murine Chagas' disease. Journal of Parasitology. 78:557-561

Rowland, E.C., M.G. Lozykowski and T.S. McCormick. 1992. Differential Cardiac Histopathology in Inbred Mouse Strains Chronically Infected with Trypanosoma cruzi. J. Parasitol. 76:1059-1066.

McCormick, T.S. and E.C. Rowland. 1993. Trypanosoma cruzi recognition of a 43Kd Muscle Glycoprotein by Auto-Antibodies present during murine infection. Exp. Parasit. 77:273-281.

Rowland, E.C. and Shumin Yang. 1993. American Trypanosomiasis. In: The Parasitology of Zoonoses (ed: Shao Huiyuan). China.

Tibbetts, R.S., T.S. McCormick, E.C. Rowland, S.D. Miller and D.M. Engman. 1994. Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi - infected mice. Journal of Immunology 152:1493-1499.

Yang, S., L.W. Bergman, D.R. Scholl and E.C. Rowland. 1994. Cloning of a partial length cDNA encoding the C-terminal portion of the 75-77 kDa antigen of Trypanosoma cruzi. Journal of Eukaryotic Microbiology: 41:435-441.

Rowland, E.C., Hong Luo and T.S. McCormick. 1995. In vivo and in vitro infection characteristics of an Ecuadorian Trypanosoma cruzi strain. Journal of Parasitology 81:123-126.

Grijalva, M.J., E.C. Rowland, M.R. Powell, T.S. McCormick and L. Escalante. 1995. Blood donors in a vector free zone of Ecuador are potentially infected with Trypanosoma cruzi. American Journal of Tropical Medicine and Hygiene 52:360-363.

Escalante, L., E.C. Rowland and M.R. Powell. 1995. Prevalence of anti-Taenia solium antibodies in sera from outpatients in an Andean region of Ecuador. Memoriás Instituto Oswaldo Cruz 90: 715-719.

Humphrey, J.S., T.S. McCormick and E.C. Rowland. 1997. Parasite antigen induced IFNgama and IL-4 production by cells from pathopermissive and pathoresistant strains of mice infected with Trypanosoma cruzi. Journal of Parasitology 83: 533-536.

Grijalva, M.J., R. Chiriboga, J.R. Racines, L. Escalante, and E.C. Rowland. 1997. Short report: Screening for Trypanosoma cruzi in the blood supply by the Red Cross blood bank in Quito, Ecuador. American Journal of Tropical Medicine and Hygiene 57: 740-741.

Grijalva, M.J., K. Goodrum and E.C. Rowland. 1999. Immunological characterization of antigens released by Trypanosoma cruzi infected cells. Journal of Parasitology. 85:663-671.

Rowland, E.C. and Z. Chen. 2003. Inhibition of Trypanosoma cruzi Egress from Infected Fibroblasts Is Mediated by CD4+ and u+ Immune Cells. Journal of Parasitology 89: 733-737.

Mario J. Grijalva, Luis Escalante, Rodrigo A. Paredes, Jaime A. Costales, Alberto Padilla, Edwin C. Rowland, H. Marcelo Aguilar and Jose Racines. 2003. Seroprevalence and Risk Factors for Trypanosoma cruzi Infection in the Amazon Region of Ecuador. American Journal of Tropical Medicine and Hygiene 69: 380-385.

Rowland, E.C., D. Moore-Lai, J.R. Seed, C.E. Stephens and D.W. Boykin. 2003. Inhibition of In Vitro Intracellular Growth of Trypanosoma cruzi by Dicationic Compounds. Journal of Parasitology 90:1078-1080.

Moore-Lai, D. and E.C. Rowland. 2004. Discovery and characterization of an egress inhibiting antibody, anti-egressin, that is able to inhibit Trypanosoma cruzi egress in vitro. Journal of Parasitology 90: 524-530.

Moore-Lai, D. and E. Rowland. 2004. Anti-egressin acts late in the intracellular growth cycle of Trypanosoma cruzi to inhibit parasite egress. Journal of Parasitology 90: 85-91.

Moore-Lai, D. and E. Rowland. 2004. Microarray data demonstrates that Trypanosoma cruzi down-regulates the expression of apoptotic genes in BALB/c fibroblasts. Journal of Parasitology 90:893-895.

Costales,J.A. and E.C. Rowland. Human Chagasic serum contains antibodies capable of inhibiting Trypanosoma cruzi egress from tissue culture cells. Journal of Parasitology - in press.

   

Presentations:

Rowland, E. and B. Lavy. "Histopathologic Study of Cardiac Tissue in Experimental Chagas' Disease. FASEB meeting April 1986, St. Louis.

Spears, K., S. Phare and E. Rowland. "Anti-heart Humoral Response in Experimental Chagas' Disease." FASEB meeting, March, 1987, Washington, D.C.

McCormick, T. and E. Rowland. "ELISA Determination of Heart Specific Antibodies in Trypanosoma cruzi Infected Mice." FASEB meeting, May, 1988, Las Vegas.

Spears, K., M. Lozykowski and E. Rowland. "Trypanosoma cruzi Antigen-Specific Antibody Response in Mice Surviving Acute Infection." FASEB meeting, May, 1988, Las Vegas.

Lozykowski, M.G., T.S. McCormick, K.R. Spears and E.C. Rowland. "Correlation of Tissue Antibody Levels and Cardiac Pathology in Mice Infected with Trypanosoma cruzi." Am. Soc. of Parasitologists Meeting, August, 1988, Winston-Salem, N.C.

McCormick, T.S. and E.C. Rowland. "Beta-Receptor Bearing Turkey Erythrocytes as the Target of Autoantibodies in Trypanosoma cruzi Infected Mice." Am. Soc. of Parasitologists Meeting, August, 1988, Winston-Salem, N.C.

Rowland, E.C., K.R. Spears and T.S. McCormick. "Relationship of Parasite Specific Antibodies and Heart Specific Autoantibodies in Mice Infected with Trypanosoma cruzi." 15th Annual Congress on Chagas' Disease. Caxambu, MG, Brazil. Nov. 7-9, 1988.

McCormick, T.S. and E.C. Rowland. "Carbohydrate Specificity of Anti-Heart Antibodies Produced During Experimental Chagas' Disease in Mice." Annual Meeting of the American Society of Tropical Medicine and Hygiene, Washington D.C., Dec. 4-8, 1988.

McCormick, T., K. Spears and E. Rowland. "Identification of Specific Heart and Parasite Targets of Autoantibodies in Murine Chagas' Disease." FASEB meeting, March 1989, New Orleans, LA.

Rowland, E.C., K. Spears-Mikhail and T.S. McCormick. "Isotype Determination of Anti-Parasite, Anti-Heart and Tissue Antibody Levels in Murine Chagas' Disease." Am. Soc. Parasitologists Meeting. Vancouver, B.C., August, 1989.

McCormick, T.S. and E.C. Rowland. "Western Blot Analysis of Heart Targets Bound by Autoantibody from Trypanosoma cruzi Infected Mice." Am. Soc. Parasitologists Meeting. East Lansing, MI, June, 1990. Also presented at FASEB Summer Workshop on "Autoimmunity." Saxons River, VT, July 1990.

McCormick, T., M. Lozykowski, J. Flannery and E. Rowland. "Anti-Heart Response and Histopathology in Resistant Inbred Mouse Strains Chronically Infected with Trypanosoma cruzi." FASEB meeting, April 1991, Atlanta, GA.

Mikhail, K.S. and E. Rowland. Soluble Antigens Released from Trypanosoma Cruzi Infected Fibroblasts are Recognized by Sera from Infected Mice. "FASEB meeting, April 1991, Atlanta, GA.

Rowland, E., K. Mikhail, M. Lozykowski and T. McCormick. "Characteristics of Infection of Inbred Mice with an Ecuadorian Strain (Guayas) of Trypanosoma cruzi with Reduced Cardiopathic Effect." Am. Soc. of Parasitologists Meeting, August, 1991, Madison, WI.

Rowland, E.C., K.S. Mikhail and J.W. Flannery. Do parasite specific responses relate to chronic histopathology in Trypanosoma cruzi infected mice? Am. Soc. of Parasitologists Meeting, August, 1992, Philadelphia, PA.

Yang, S., L.W. Bergman, D.R. Scholl and E.C. Rowland. Cloning and characterization of cDNA encoding a Grp 78 homologue of Trypanosoma cruzi. Am. Soc. of Parasitologists Meeting. August, 1992, Philadelphia, PA.

McCormick, T., J. Humphrey and E. Rowland. Relationship of immune responses in patho-permissive and patho-resistant strains of mice infected with Trypanosoma cruzi. Am. Soc. of Immunologists Meeting. May, 1993, Denver, CO.

Luo, H. and E. Rowland, In Vitro infection characteristics of two strains of Trypanosoma cruzi. Am. Soc. of Parasitologists Meeting. November, 1993, Atlanta, GA.

Escalante, L., M.J. Grijalva, E.C. Rowland, M.R. Powell and T.S.. McCormick. Blood donors in a vector free zone of Ecuador are potentially infected with Trypanosoma cruzi. Am. Soc. of Tropical Medicine and Hygiene Meeting. November, 1993, Atlanta, GA.

Chen, Zhuo and E. Rowland. Enhanced resistance to Trypanosoma cruzi infection by immunization with an attenuated strain. Am. Soc. of Parasitologists meeting. August, 1994, Ft. Collins, CO.

Rowland, E.C. Problems and promise of a mouse mode for Trypanosoma cruzi immunization. Eight International Congress of Parasitology. October, 1994, Izmir, Turkey.

Sleeper, A. and E.C. Rowland. cell Transfer of resistance to repeat Trypanosoma cruzi infection in mice. Am. Soc. of Parasitologists meeting. July, 1995, Pittsburgh, PA.

Chen, Z. and E.C. Rowland. Immune response to Trypanosoma cruzi Grp 78 delivered intramuscularly as naked DNA in a eukaryotic expression vector. Southeastern Society of Parasitologists Meeting. April, 1996, Murray, KY.

Powell, M.R., J. Morgan, E.C. Rowland and D.G. Colley. Trypanosoma cruzi: cytokine mRNA expression in the hearts of pathoresistant vs pathopermissive strains of inbred mice. Am. Soc. of Parasitologists Meeting. June, 1996, Tucson, AZ.

Grijalva, M.J., K. Goodrum and E.C. Rowland. Monoclonal antibody to antigen released from Trypanosoma cruzi infected fibroblasts recognizes an epitope expressed during the intracellular transformation of amastigotes into trypomastigotes. Am. Soc. of Parasitologists Meeting. June, 1996, Tucson, AZ.

Powell, M.R., E.C. Rowland, J. Gaurner, J.P. Sypek, M.J. Grijalva, and D.G. Colley. Alteration of the degree of Trypanosoma cruzi-associated cardiac damage by injection with antibodies specific for IL-4 or IL-12. American Society of Tropical Medicine and Hygiene Meeting, Washington D.C., Nov. 28-Dec. 2, 1999.

Racines, J.R., L. Escalante, M.H. Aguilar, J.A. Costales, R.A. Paredes, M. Sanchez, E.C. Rowland, and M.J. Grijalva. Chagas disease in Ecuador: seroprevalence in endemic areas and blood banks. American Society of Tropical Medicine and Hygiene Meeting, Washington D.C., Nov. 28-Dec. 2, 1999.

Lai, D. M. ,J. Costales and E. Rowland. Inhibition of Trypanosoma cruzi release involves the interaction of IgG2a from chronic sera and a 98 kD host cell membrane component. International Congress of Parasitology (ICOPA X), August 4-9, 2002, Vancouver, BC, Canada.

Costales. J and E. Rowland. Chagas positive human serum inhibits the egress of Trypanosoma cruzi from tissue culture cells. American Society of Parasitologists Meeting. August1-5, 2003. Halifax, Nova Scotia.

Rowland, E.C. Teaching Medical Parasitology in a clinical presentation curriculum. American Society of Parasitologists Meeting. August 1-5, 2003. Halifax, Nova Scotia.

Costales, J.A. and E.C. Rowland. Antibodies present in Chagas positive human serum inhibit the egress of Trypanosoma cruzi from tissue culture cells. American Society for Tropical Medicine and Hygiene Meeting. December 3-7, 2003. Philadelphia, PA.

Costales, J.A. and E.C. Rowland. An alpha-1-antitrypsin containing protein complex, located on the surface of Trypanosoma cruzi infected cells, may be the target of anti-egressin. Southeastern Society of Parasitologists Meeting. April 14-16, 2004. Pigeon Forge, TN.

Costales, J.A. and E.C. Rowland. The target for anti-egressin may be a cell surface protein complex that contains alpha-1-antitrypsin. Meeting of the American Society of Parasitologists. July 24-28, 2004. Philadelphia, PA.

 
   
   
  Ohio University
Heritage College of Osteopathic Medicine
Irvine Hall, Athens, Ohio 45701
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Last updated: 08/14/2014